Anti-JMJD2C Antibody (D-4) is a mouse monoclonal IgG2a κ JMJD2C antibody, cited in 2 publications, provided at 200 µg/ml
specific for an epitope mapping between amino acids 903-926 within an internal region of JMJD2C of human origin
Anti-JMJD2C Antibody (D-4) is recommended for detection of JMJD2C of mouse, rat and human origin by WB, IP, IF and ELISA
Anti-JMJD2C Antibody (D-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of JMJD2C (D-4): sc-515767.
m-IgG2a BP-HRP is the preferred secondary detection reagent for JMJD2C Antibody (D-4) for WB applications. This reagent is now offered in a bundle with JMJD2C Antibody (D-4) (see ordering information below).
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
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Labware ships FedEx Ground free of charge to the contiguous US
JMJD2C Antibody (D-4) is a high quality monoclonal JMJD2C antibody (also designated JMJD2C antibody) suitable for the detection of the JMJD2C protein of mouse, rat and human origin. JMJD2C Antibody (D-4) is available as both the non-conjugated anti-JMJD2C antibody form, as well as multiple conjugated forms of anti-JMJD2C antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. JMJD2C (jumonji domain containing 2C), also known as GASC1, KDM4C or JHDM3C, is a nuclear protein that belongs to the Jumonji domain 2 (JMJD2) family of histone demethylases. Functioning as a trimethylation-specific demethylase, JMJD2C demethylates specific lysine residues of Histone H3, thereby converting the trimethylated Histone H3 to its dimethylated form and playing a central role in the histone code. Through its ability to modify histones, JMJD2C increases the rate of cell proliferation and promotes the expression of a variety of proteins. JMJD2C binds iron as a cofactor and contains two Tudor domains through which it interacts with methylated histones. Overexpression of JMJD2C is associated with esophageal squamous cell carcinoma, suggesting a possible role for JMJD2C in carcinogenesis. Two isoforms of JMJD2C exist due to alternative splicing events.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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