JLK 6 CAS: 62252-26-0
MF: C10H8ClNO3
MW: 225.63
An inhibitor of γ-secretase, selectively inhibits βAPP cleavage.

JLK 6 (CAS 62252-26-0)

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Synonym: 7-Amino-4-chloro-3-methoxy-1H-2-benzopyran
Application: An inhibitor of γ-secretase, selectively inhibits βAPP cleavage
CAS Number: 62252-26-0
Purity: ≥99%
Molecular Weight: 225.63
Molecular Formula: C10H8ClNO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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JLK 6 is an inhibitor of γ-secretase that selectively inhibits βAPP cleavage without affecting other γ-secretase-mediated pathways. JLK 6 prevents recovery of Aβ40 and Aβ42 from HEK293 cells overexpressing wild-type or Swedish-mutated βAPP (IC50 ~ 30 µM). It displays no effect on notch cleavage and notch-mediated intracellular signaling, BACE1, BACE2, α-secretase, the proteosome, or GSK3β.


References

1. Petit, A., et al. 2001. Nat. Cell. Biol. 3: 507-511.
2. Petit, A., et al. 2003. J. Neurosci. Res. 74: 370-377.
3. Hellstrom, M., et al. 2007. Nature. 445: 776-780.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (25 mM).
Storage :
Store at room temperature
Melting Point :
173-175° C
Boiling Point :
456.14° C at 760 mmHg (Predicted)
Density :
1.46 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
Swedish-mutated β4APP: IC50 = ~30 µM; Aβ40 and Aβ42: IC50 = <100 µM
pK Values :
pKb: 1.95 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3803
MDL Number :
MFCD04035584
SMILES :
COC1=C(C2=C(C=C(C=C2)N)C(=O)O1)Cl

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Certificate of Analysis

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