Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling. This is derived from the Veratrum plant species. It is a close structural analog of cyclopamine which specifically inhibits the hedgehog (Hh) pathway by interaction with the hedgehog signaling protein Smo. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Jervine is an inhibitor of Smo.
1. Incardona, J.P., et al. 2000. Dev. Biol. 224: 440-452. PMID: 10926779 2. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. U.S.A. 99: 14071-14076. PMID: 12391318 3. Mistretta, C.M., et al. 2003. Dev. Biol. 254: 1-18. PMID: 12606278 4. ten Berge, D., et al. 2001. Development. 128: 2929-2938. PMID: 11532916
Soluble in ethanol (10 mg/ml warm), DMF (6 mg/ml), DMSO (5 mg/ml), methanol (>2 mg/ml), chloroform, and dichloromethane. Insoluble in water.
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