JAK3 Inhibitor V CAS: 4452-06-6
MF: C13H10O
MW: 182.22
A selective JAK3 inhibitor.

JAK3 Inhibitor V (CAS 4452-06-6)

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Alternate Names: 1-(2-Naphthalenyl)-2-propen-1-one
Application: JAK3 Inhibitor V is a selective JAK3 inhibitor
CAS Number: 4452-06-6
Purity: ≥98%
Molecular Weight: 182.22
Molecular Formula: C13H10O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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JAK3 Inhibitor V is a potent, selective inhibitor of JAK3 (Janus tyrosine kinase 3) which binds competitively to the JAK3 ATP site. pIC50 values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. JAK3 Inhibitor V inhibits STAT-5 phosphorylation and T-cell proliferation.


References

Brown, G.R., et al. 2000. Bioorg. Med. Chem. Lett. 10, 575.

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), and ethanol (10 mg/ml).
Storage :
Store at -20° C
Melting Point :
75.35° C (Predicted)
Boiling Point :
~319.3° C at 760 mmHg (Predicted)
Density :
1.10 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Inhibition of JAK-mediated interferon-gamma-induced Stat1 phosphorylation: IC50 < 20 µM (BALB/c mouse CD8++ T cells); Inhibition of JAK-mediated interferon-gamma-induced Stat1 phosphorylation: IC50 < 20 µM (BALB/c mouse CD4+ T cells); Inhibition of JAK-mediated IL6-induced Stat3 phosphorylation: IC50 < 20 µM (BALB/c mouse CD11b-hi neutrophils); Inhibition of JAK-mediated IL7-induced Stat5 phosphorylation: IC50 < 20 µM (BALB/c mouse CD11b-hi neutrophils); Inhibition of JAK-mediated IL15-induced Stat5 phosphorylation: IC50 < 20 µM (BALB/c mouse CD4+ T cells)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD04974535
SMILES :
C=CC(=O)C1=CC2=CC=CC=C2C=C1

Download SDS (MSDS)

Certificate of Analysis

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