JAK3 Inhibitor V is a potent, selective inhibitor of JAK3 (Janus tyrosine kinase 3) which binds competitively to the JAK3 ATP site. pIC50 values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. JAK3 Inhibitor V inhibits STAT-5 phosphorylation and T-cell proliferation.
Brown, G.R., et al. 2000. Bioorg. Med. Chem. Lett. 10, 575.