J 104129 fumarate (CAS 244277-89-2)
Alternate Names:
(αR)-α-Cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide fumarate
Application:
J 104129 fumarate is a mAChR M3 antagonist
CAS Number:
244277-89-2
Purity:
≥99%
Molecular Weight:
500.63
Molecular Formula:
C24H36N2O2•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
J 104129 is a potent mAChR M3 antagonist that displays ~ 120-fold selectivity over mAChR M2 (Ki values are 4.2, 19 and 490 nM for human mAChR M3, mAChR M1 and mAChR M2 receptors, respectively). J 104129 exhibits > 250-fold bronchial selectivity. It inhibits ACh-induced bronchoconstriction but not ACh-induced bradycardia (KB values are 3.3 and 170 nM for rat trachea mAChR M3 and rat right atria mAChR M2 receptors, respectively).
References
1. Mitsuya, M., et al. 1999. Bioorg. Med. Chem. 7: 2555-2567.
2. Mitsuya, M., et al. 1999. Bioorrg. Med .Chem. Lett. 9: 2037-2038.
3. Mitsuya, M., et al. 2000. Bioorg. Med. Chem. 8: 825-832.
Physical State
:
Solid
Solubility
:
Soluble in DMSO (100 mM), and ethanol (50 mM).
Storage
:
Store at 4° C
Optical Activity
:
α20/D -7.2°, c = 1.0 in Methanol
Ki Data
:
M3 receptor: Ki= 4.2 nM (human); M1 receptor : Ki= 19 nM (human); M2 receptor: Ki= 490 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
PubChem CID
:
MDL Number
:
MFCD09753272
SMILES
:
CC(=CCCN1CCC(CC1)NC(=O)[[email protected]@](C2CCCC2)(C3=CC=CC=C3)O)C.C(=CC(=O)O)C(=O)O
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Certificate of Analysis
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What are the storage conditions after dissolving?
Thank you for your question. For this chemical, J 104129 fumarate: sc-203610, aliquoted stock solutions can be stored in tightly sealed vials at -20ºC, however it is recommended that solutions be made and used same day.
Date published: 2016-12-14