IWR-1-exo is a diastereomer of IWR-1-endo (sc-295215) which is the active inhibitor of the Wnt signaling pathway. IWR-1-endo displays an IC50 = 180 nM, which inhibits the Wnt/β-catenin pathway reporter. These studies suggest that IWR-1-exo is an ideal negative control in these tests because it has little effect on the Wnt pathway at 10μM compared its active form, IWR-1-endo. The Wnt signaling pathway is an important cascade involved in homeostasis, embryonic development, and tumorigenesis. Currently, IWR-1-exo along with its active form, are essential in cancer research, as it is believed that the Wnt pathway is a main target to inhibiting several cancers.
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