IWR-1-exoAn inhibitor of the Wnt/β-catenin pathway

IWR-1-exo (CAS 1127442-87-8)

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Application: An inhibitor of the Wnt/β-catenin pathway
CAS Number: 1127442-87-8
Purity: ≥98%
Molecular Weight: 409.44
Molecular Formula: C25H19N3O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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IWR-1-exo is a diastereomer of IWR-1-endo (sc-295215) which is the active inhibitor of the Wnt signaling pathway. IWR-1-endo displays an IC50 = 180 nM, which inhibits the Wnt/β-catenin pathway reporter. These studies suggest that IWR-1-exo is an ideal negative control in these tests because it has little effect on the Wnt pathway at 10μM compared its active form, IWR-1-endo. The Wnt signaling pathway is an important cascade involved in homeostasis, embryonic development, and tumorigenesis. Currently, IWR-1-exo along with its active form, are essential in cancer research, as it is believed that the Wnt pathway is a main target to inhibiting several cancers.


References

1. Souren, J.E., et al. 1992. In Vitro Cell. Dev. Biol. 28A: 199-204. PMID: 1582995
2. Polakis, P., 2000. Genes Dev. 14: 1837-1851. PMID: 10921899
3. Clevers, H., 2006. Cell. 127: 469-480. PMID: 17081971
4. Lu, J., et al. 2009. Bioorg. Med. Chem. Lett. 19: 3825-3827. PMID: 19410457
5. Chen, B., et al. 2009. Nat. Chem. Biol. 5: 100-107. PMID: 19125156
6. Huang, S.M., et al. 2009. Nature. 461: 614-620. PMID: 19759537

Physical State :
Solid
Solubility :
Soluble in chloroform (~1 mg/ml), DMSO (~0.3 mg/ml), DMF (~5 mg/ml), and 1:3 solution of DMF:PBS (pH 7.2) (~0.25 mg/ml).
Storage :
Store at -20° C
Refractive Index :
n20D ~1.74 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
68315684
SMILES :
[H][C@]12[C@](C(N(C3=CC=C(C(NC4=CC=CC5=C4N=CC=C5)=O)C=C3)C2=O)=O)([H])[C@@H]6C=C[C@H]1C6

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Certificate of Analysis

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IWR-1-exo  Product Citations

See how others have used IWR-1-exo. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26048374  Mathur, R. et al. 2015. J Hematol Oncol. 8: 63.

Citations 1 to 1 of 1 total
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