IvermectinA positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor

Ivermectin (CAS 70288-86-7)

Ivermectin | CAS 70288-86-7 is rated 5.0 out of 5 by 1.
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Application: A positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor
CAS Number: 70288-86-7
Purity: ≥98%
Molecular Weight: 875.1
Molecular Formula: C48H74O14 (B1a form)
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ivermectin is a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Ivermectin acts as an antihelmintic. Ivermectin also modulates glutamate- and GABA-activated chloride channel and potentiates glycine-gated currents at low concentrations (30 nM).


References

1. Krause, R.M., et al. 1998. Mol.Pharmacol. 53: 283-294.
2. Khakh, B.S., et al. 1999. J. Neurosci. 19: 7289-7299.
3. Adelsberger, H., et al. 2000. Eur. J. Pharmacol. 394: 163-170.
4. Shan, Q., et al. 2001. J. Biol. Chem. 276: 12556-12564.

Physical State :
Solid
Solubility :
Soluble in methyl ethyl ketone (50 mg/ml), and DMSO (50 mM).
Storage :
Desiccate at 4° C
Melting Point :
~155° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
IH7891500
PubChem CID :
11957587
MDL Number :
MFCD00869511
EC Number :
274-536-0
SMILES :
CC[C@@H](C)[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\\C)C

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Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. This chemical is supplied as white or yellow crystalline powder. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2017-01-16

Can you please let me know the storage and stability of this compound once it is in solution (either DMSO or water)?

Asked by: two2igm05
Thank you for your question. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-21
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Rated 5 out of 5 by from Excellent quality characteristic of SCBT Our firm has been a customer of SCBT for about 4 years. We've ordered a number of specialty reagents from SCBT and have always been satisfied with our purchases. Our purchase of this particular product, Ivermectin (CAS # 70288-86-7), was no exception. The quality of the compound was second to none as was the service provided by SCBT staff. All of our questions about this and other products were answered in a timely manner by a knowledgeable professional. SCBT receives high marks from our firm in every area. SCBT goes the extra mile when it comes to ensuring customer satisfaction. We have always been impressed with SCBT and for this reason we will remain loyal customers far into the foreseeable future. Thank you!
Date published: 2018-05-08
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