ITSA1 (N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide) is an HDAC activator via TSA suppression, but shows no activity towards other HDAC inhibitors. TSA (Trichostatin A) is an inhibitor of histone deacetylase. ITSA1 was found to specifically counteract TSA-induced cell cycle arrest, histone acetylation, transcriptional activation, and cytoplasmic alpha-tubulin acetylation.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Koeller et alKoeller et al. (PubMed ID 12770822) found that the HDAC inhibitor trichostatin A (ITSA1) induced cell cycle arrest, histone acetylation, and transcriptional activation. -SCBT Publication Review
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