Itraconazole-d5 (Major) (CAS 1217510-38-7)
See product citations (1)
QUICK LINKS
Itraconazole-d5 is a deuterium-labeled analog of itraconazole, used in scientific studies as an internal standard for mass spectrometry-based bioanalytical methods. This compound is particularly in biochemical research, where it aids in the precise quantification of itraconazole by compensating for potential variations in the analytical process. Research involving Itraconazole-d5 typically focuses on the absorption, distribution, and metabolic fate of itraconazole within biological systems. It is also employed in the study of chemical interactions and the effects of genetic polymorphisms on the metabolism of itraconazole. The incorporation of deuterium atoms minimizes the chemical distinction from the parent compound while providing a detectable difference in mass, allowing for more accurate and reliable measurements in complex biological matrices.
Itraconazole-d5 (Major) (CAS 1217510-38-7) References
- Multiplex ultra-performance liquid chromatography-tandem mass spectrometry method for simultaneous quantification in human plasma of fluconazole, itraconazole, hydroxyitraconazole, posaconazole, voriconazole, voriconazole-N-oxide, anidulafungin, and caspofungin. | Decosterd, LA., et al. 2010. Antimicrob Agents Chemother. 54: 5303-15. PMID: 20855739
- Immobilization of protein-coated drug nanoparticles in nanofibrillar cellulose matrices--enhanced stability and release. | Valo, H., et al. 2011. J Control Release. 156: 390-7. PMID: 21802462
- Development of a simple liquid chromatography-tandem mass spectrometry method for multiresidue determination of antifungal drugs in chicken tissues. | Yu, Y., et al. 2011. J AOAC Int. 94: 1650-8. PMID: 22165031
- A rapid UPLC-MS/MS assay for the simultaneous measurement of fluconazole, voriconazole, posaconazole, itraconazole, and hydroxyitraconazole concentrations in serum. | Basu, SS., et al. 2017. Clin Chem Lab Med. 55: 836-844. PMID: 27866173
- Sensitive and selective quantification of total and free itraconazole and hydroxyitraconazole in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry. | Suzuki, Y., et al. 2017. Clin Biochem. 50: 1228-1236. PMID: 28928005
- In vitro studies with R 51,211 (itraconazole). | Espinel-Ingroff, A., et al. 1984. Antimicrob Agents Chemother. 26: 5-9. PMID: 6089654
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Itraconazole-d5 (Major), 1 mg | sc-280871 | 1 mg | $336.00 | |||
Itraconazole-d5 (Major), 10 mg | sc-280871A | 10 mg | $1999.00 |