Isotetrandrine CAS: 477-57-6
MF: C38H42N2O6
MW: 622.80
A biscoclaurine alkaloid inhibitor of G protein activation of PLA2.

Isotetrandrine (CAS 477-57-6)

Isotetrandrine | CAS 477-57-6 is rated 5.0 out of 5 by 1.
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Alternate Names: Berbamine methyl ether
Application: Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2
CAS Number: 477-57-6
Purity: 98%
Molecular Weight: 622.80
Molecular Formula: C38H42N2O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2 but not PLC or PLD. It has been suggested that isotetrandrine suppresses the receptor-mediated phospholipase A2 activation by uncoupling a GTP-binding protein from the enzyme. Isotetrandrine has been reported to inhibit collagen, thrombin, and arachidonic acid-induced platelet aggregation. Isotetrandrine has been found to inhibit arachidonic acid liberation of platelets induced by compound 48/80, antigen, GTPβS and Ca2+. Isotetrandrine is an inhibitor of AR (α1 adrenoceptor).


References

1. Hashizume, T., et al. 1991. Biochem. Pharmacol. 41: 419-423. PMID: 1899790
2. Akiba, S., et al. 1992. Biochem. Pharmacol. 44: 45-50. PMID: 1632837

Physical State :
Solid
Solubility :
Soluble in ethanol (25 mg/ml), DMSO (20 mg/ml), acetone, and chloroform.
Storage :
Store at -20° C
Boiling Point :
~710.5° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.59
IC50 :
Dopamine transporter: IC50 = 4.2 µM (Rattus norvegicus)
pK Values :
pKb: 7.70
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
NX7285000
PubChem CID :
SMILES :
CN1CCC2=CC(=C3C=C2[[email protected]@H]1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)C[[email protected]@H]6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC

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Certificate of Analysis

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Isotetrandrine (CAS 477-57-6)  Product Citations

See how others have used Isotetrandrine (CAS 477-57-6). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 32503690  Xu, W.|Chen, S.|Wang, X.|Wu, H.|Yamada, H.|Hirano, T.| et al. 2020. Bioorg Med Chem. 28: 115553.

PMID: # 33296524  Clin Exp Dermatol.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Akiba et al Akiba et al. (PubMed ID 1632837) used Isotetrandrine to inhibit antigen and compound-induced arachidonic acid liberation in peritoneal mast cells. -SCBT Publication Review
Date published: 2015-07-16
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