IsorhamnetinAn antiviral, antioxidant apoptosis inducer

Isorhamnetin (CAS 480-19-3)

Isorhamnetin | CAS 480-19-3 is rated 5.0 out of 5 by 1.
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Synonym: 3-Methylquercetin; Quercetin-3′-methyl ether
Application: An antiviral, antioxidant apoptosis inducer
CAS Number: 480-19-3
Purity: ≥98%
Molecular Weight: 316.26
Molecular Formula: C16H12O7
* Refer to Certificate of Analysis for lot specific data (including water content).
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Isorhamnetin is an antiviral agent. Additionally, isorhamnetin acts as an antioxidant, an antitumor compound, and an apoptosis inducer.


References

1. Ito, H., et al., 1999. Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima. Cancer letters. 143(1): 5-13. PMID: 10465331
2. Nagao, A., et al., 1999. Inhibition of xanthine oxidase by flavonoids. Bioscience, biotechnology, and biochemistry. 63(10): 1787-90. PMID: 10671036
3. Zou, L., et al., 2002. Effects of intrinsic fluorescence and quenching on fluorescence-based screening of natural products. Phytomedicine : international journal of phytotherapy and phytopharmacology. 9(3): 263-7. PMID: 12046870
4. Yokozawa, Takako., et al., 2002. Antioxidant effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes. Journal of agricultural and food chemistry. 50(19): 5490-5. PMID: 12207497
5. Chen, Guang., et al., 2002. Effect of five flavonoid compounds isolated from leaves of Diospyros kaki on stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils. Clinica chimica acta; international journal of clinical chemistry. 326(1-2): 169-75. PMID: 12417109
6. Bao, Meihua., et al., 2006. Isorhamnetin prevent endothelial cell injuries from oxidized LDL via activation of p38MAPK. European journal of pharmacology. 547(1-3): 22-30. PMID: 16963021
7. Ma, Gang., et al., 2007. The flavonoid component isorhamnetin in vitro inhibits proliferation and induces apoptosis in Eca-109 cells. Chemico-biological interactions. 167(2): 153-60. PMID: 17368593

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in acetone, methanol, DMSO, ethylacetate, and water (sparingly).
Storage :
Store at 4° C
Melting Point :
200° C
Boiling Point :
~599.43° C at 760 mmHg (Predicted)
Density :
1.63 g/cm3 (Predicted)
Refractive Index :
n20D 1.74 (Predicted)
IC50 :
Cytochrome P450 1B1: IC50 = 17 nM (human); Cytochrome P450 1A1: IC50 = 56 nM (human); Enoyl-acyl-carrier protein reductase: IC50 = 5 µM (Plasmodium falciparum); 3-oxoacyl-acyl-carrier protein reductase: IC50 = 8.3 µM (Plasmodium falciparum)
pK Values :
pKa: 6.31 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
LK9275450
PubChem CID :
5281654
MDL Number :
MFCD00017310
EC Number :
207-545-5
Beilstein Registry :
44723
SMILES :
COC1=C(C=CC(=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O

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Certificate of Analysis

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Isorhamnetin  Product Citations

See how others have used Isorhamnetin. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 28248427  Paasela, T. et al. 2017. New Phytol. 214: 1537-1550.

PMID: # 28160865  Ahn, H. et al. 2017. Phytomedicine. 24: 77-86.

PMID: # 26157553  2015. Biomol Ther (Seoul). 23: 357-66.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Ruan Ruan, Y. et al. (PubMed 26238746) reported that autophagy inhibition enhances Isorhamnetin induced mitochondria dependent apoptosis in non small cell lung cancer cells. -SCBT Publication Review
Date published: 2015-06-24
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