IsoliquiritigeninA soluble guanylyl cyclase activator

Isoliquiritigenin (CAS 961-29-5)

Isoliquiritigenin | CAS 961-29-5 is rated 5.0 out of 5 by 1.
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Synonym: (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
Application: A soluble guanylyl cyclase activator
CAS Number: 961-29-5
Purity: ≥97%
Molecular Weight: 256.25
Molecular Formula: C15H12O4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Isoliquiritigenin is a soluble guanylyl cyclase activator. Possesses antitumor activity.


References

1. Yu, et al., Vasorelaxant effect of isoliquiritigenin a novel soluble guanylate cyclase activator in rat aorta. Br. J. Pharmacol. 114, 1587-1594, (1995) 2. Tawata, et al., Anti-platelet action of isoliquiritigeninan aldose reductase inhibitor in licorice. Eur. J. Pharmacol. 212, 87-92, (1992) 3. Yamamoto, et al., The potent anti-tumor-promoting agent isoliquiritigenin. Carcinogenesis 12, 317-323, (1991)

Physical State :
Solid
Solubility :
Soluble in water: <0.1 mg/mL: methanol: 10 mg/mL: DMSO: 20 mg/mL
Storage :
Store at 4° C
Melting Point :
≥ 260° C (lit.)
Boiling Point :
504.0±42.0° C at 760 mmHg (Predicted)
Density :
1.4±0.1 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
638278
SMILES :
C1=CC(=CC=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Wu et al Wu et al. (PubMed ID 26383911) found that isoliquiritigenin attenuated inflammatory mechanisms of psoriasis by suppressing NF-kB activity. -SCBT Publication Review
Date published: 2015-02-07
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