Isohelenin, Inula sp.A cell-permeable sesquiterpene lactone that acts as an irreversible inhibitor of NF-κB activation

Isohelenin, Inula sp.

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Application: A cell-permeable sesquiterpene lactone that acts as an irreversible inhibitor of NF-κB activation
Purity: ≥95%
Molecular Weight: 232.3
Molecular Formula: C15H20O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Isohelenin, Inula sp. is a cell-permeable sesquiterpene lactone with anti-inflammatory properties. A highly specific, potent, irreversible inhibitor of NF-κB activation that prevents IκBα degradation. Does not affect the DNA binding activity of activated NF-κB, or inhibit p59fyn and Src kinase activities. Inhibits IL-8 gene expression in cultured human respiratory epithelium in vitro, and iNOS gene expression in cultured rat aortic smooth muscle cells.


References

Sheehan, M., et al. 2002. J. Endotoxin. Res. 8, 99. Mazor, R.L., et al. 2000. Cytokine 12, 239. Wong. H.R., and Menendez, I.Y., 1999. Biochem. Biophys. Res. Commun. 262, 375. Hehner, S.P., et al. 1998. J. Biol. Chem. 273, 1288. Bork, P.M., et al. 1997. FEBS Lett. 402, 85.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml), and ethanol (20 mg/ml).
Storage :
Store at -20° C
Melting Point :
103.35° C (Predicted)
Boiling Point :
~364.9° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.53 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10130839
SMILES :
C[C@]12CCCC(=C)C1C[C@H]3C(C2)OC(=O)C3=C

Download SDS (MSDS)

Certificate of Analysis

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