Irinotecan Carboxylate Sodium SaltA carboxylated Topo I inhibitor

Irinotecan Carboxylate Sodium Salt

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Synonym: (αS)-2-[([1,4-Bipiperidin]-1-ylcarbonyl)oxy]-α,12-diethyl-9,11-dihydro-α-hydroxy-8-(hydroxymethyl)-9-oxo-indolizino[1,2-b]quinoline-7-acetic Acid Sodium Salt; CPT 11 Carboxylic Acid Sodium Salt
Application: A carboxylated Topo I inhibitor
Molecular Weight: 626.68
Molecular Formula: C33H39NaN4O7
* Refer to Certificate of Analysis for lot specific data (including water content).
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Irinotecan Carboxylate Sodium Salt is the carboxylate form of Irinotecan (sc-202186), a DNA Topo I (topoisomerase I) inhibitor.


References

Kunimoto, T., et al.: Cancer Res., 47, 5944 (1987) Shimada, Y., et al.: J. Clin. Oncol., 11, 909 (1993) Chen, A., et al.: Annu. Rev. Pharmacol. Toxicol., 34, 191 (1994)

Solubility :
Soluble in DMSO, and water.
Storage :
Store at -20° C
Melting Point :
185-188°C (lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
46781988
SMILES :
CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC(=C(C4=O)CO)[C@@](CC)(C(=O)[O-])O)OC(=O)N5CCC(CC5)N6CCCCC6.[Na+]

Download SDS (MSDS)

Certificate of Analysis

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