(+)-IrinotecanA Topo I inhibitor

(+)-Irinotecan (CAS 97682-44-5)

(+)-Irinotecan | CAS 97682-44-5 is rated 5.0 out of 5 by 1.
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Application: A Topo I inhibitor
CAS Number: 97682-44-5
Purity: ≥97%
Molecular Weight: 586.69
Molecular Formula: C33H38N4O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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(+)-Irinotecan is an isomer of the Topo I inhibitor Irinotecan (sc-202186).

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
222-223° C
Boiling Point :
~873.4° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
A375: IC50 = 4 nM (human); PC-3: IC50 = 4 nM (human); LNCaP: IC50 = 9 nM (human); NCI-H460: IC50 = 15 nM (human); H69: IC50 = 22 nM (human)
Ki Data :
AChE: Ki= 26.4 nM (human); mAChR M4: Ki= 217 nM (human); α2C-AR: Ki= 461 nM (human); CYP3A4: Ki= 24 µM (human)
pK Values :
pKa: 11.2 (Predicted), pKb: 9.33 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
DW1061000
PubChem CID :
60838
Merck Index :
14: 5091
MDL Number :
MFCD00866307
SMILES :
CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)[C@@]5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Wong Wong, DV. et al. (PubMed 26440613) used the Topo I inhibitor (+)-Irinotecan to induce intestinal mucositis in MyD88-, TLR2- or TLR9-knockout mice and C57BL/6 (WT) mice . -SCBT Publication Review
Date published: 2015-03-24
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