Anti-IP3R-I Antibody (E-8) is a mouse monoclonal IgG1 κ IP3R-I antibody, cited in 11 publications, provided at 200 µg/ml
raised against amino acids 1894-1973 mapping within a cytoplasmic domain of IP3R-I of human origin
Anti-IP3R-I Antibody (E-8) is recommended for detection of IP3R-I of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
Anti-IP3R-I Antibody (E-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of IP3R-I (E-8): sc-271197.
m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IP3R-I Antibody (E-8) for WB and IHC(P) applications. These reagents are now offered in bundles with IP3R-I Antibody (E-8) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
IP3R-I Antibody (E-8) is a high quality monoclonal IP3R-I antibody (also designated INSP3R1, IP3R1, IP3R antibody, intracellular receptor for inositol 1,4,5-trisphosphate antibody, inositol 1,4,5-trisphosphate receptor antibody, endoplasmic reticulum calcium channel antibody, C-terminal calcium channel / N-terminal ligand-binding receptor for inositol 1,4,5-trisphosphate antibody, or exocrine secretion, energy metabolism and growth related antibody) suitable for the detection of the IP3R-I protein of mouse, rat and human origin. IP3R-I Antibody (E-8) is available as both the non-conjugated anti-IP3R-I antibody form, as well as multiple conjugated forms of anti-IP3R-I antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4,5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1,4,5- triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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