INH2BPA cell permeable PARP inhibitor

INH2BP (CAS 137881-27-7)

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Synonym: 5-Iodo-6-amino-1,2-benzopyrone; PARP Inhibitor II
Application: A cell permeable PARP inhibitor
CAS Number: 137881-27-7
Purity: ≥98%
Molecular Weight: 287.05
Molecular Formula: C9H6INO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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INH2BP is a cell-permeable poly(ADP-ribose) polymerase (PARP-1) inhibitor. It offers protection against peroxynitrite and hydroxyl radicals in vitro and abrogates peroxynitrite-induced mitochondrial transmembrane potential (ΔΨm) reduction. INH2BP also exhibits malignant phenotype reversal in cancer cells and inhibits HIV-1 IIIb replication in vitro.


References

Szabó, C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3867. Szabó, C. 1998. Shock 9, 341. Virag, L., et al. 1998. J. Immunol. 161, 3753. Bauer, P.I., et al. 1995. Biochimie 77, 374. Cole, G.A., et al. 1991. Biochem. Biophys. Res. Commun. 180, 504.

Physical State :
Solid
Solubility :
Soluble in DMSO (31 mg/ml). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
139.94° C (Predicted)
Boiling Point :
~437.6° C at 760 mmHg (Predicted)
Density :
~2.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.74 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
72356
MDL Number :
MFCD00912555
SMILES :
C1=CC(=O)OC2=C1C(=C(C=C2)N)I

Download SDS (MSDS)

Certificate of Analysis

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