INH2BP is a cell-permeable poly(ADP-ribose) polymerase (PARP-1) inhibitor. It offers protection against peroxynitrite and hydroxyl radicals in vitro and abrogates peroxynitrite-induced mitochondrial transmembrane potential (ΔΨm) reduction. INH2BP also exhibits malignant phenotype reversal in cancer cells and inhibits HIV-1 IIIb replication in vitro.
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