Ingenol is an extremely weak PKC (protein kinase C) activator. Has been found to induce apoptosis and act as an anticancer agent. Ingenol derivatives have received constant and multidisciplinary attention on account of their pleiotropic pattern of biological activity. This includes activation of PKC (protein kinase C), tumor-promotion, anticancer, and anti-HIV properties, and the possibility of dissecting co-cancerogenic and clinically useful activities has been demonstrated. Certain ingenol esters show powerful anticancer activity, and a structure-activity relationship model to discriminate between their apoptotic and non-apoptotic properties has been developed. Ingenol is an activator of PKC ε and PKC δ.
1. Hasler, C.M., et al. 1992. Cancer Res. 52: 202-208. PMID: 1727380 2. Armstrong, S. and Gonote, C.E. 1994. Cardiovasc. Res. 28: 1700-1706. PMID: 7842465 3. Kuwajima, I. and Tanino, K. 2005. Chem. Rev. 105: 4661-4670. PMID: 16351057
Soluble in DMSO, ethanol, water (partly), hexane, and chloroform (10 mg/ml).
Store at 4° C
213.18° C (Predicted)
523.79° C at 760 mmHg (Predicted)
1.34 g/cm3 (Predicted)
n20D 1.63 (Predicted)
PKC: Ki= 30 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Rated 5 out of
HaslerHasler, CM. et al. (PubMed 1727380) examined the ability of Ingenol to bind to and activate protein kinase C and to induce similar responses to the phorbol esters in biological systems. Their data demonstrated that Ingenol binds to protein kinase C with a Ki of 30 M and activates the enzyme. -SCBT Publication Review
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