IngenolA weak protein kinase C activator

Ingenol (CAS 30220-46-3)

Ingenol | CAS 30220-46-3 is rated 5.0 out of 5 by 1.
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Application: A weak protein kinase C activator
CAS Number: 30220-46-3
Purity: >98%
Molecular Weight: 348.4
Molecular Formula: C20H28O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ingenol is an extremely weak PKC (protein kinase C) activator. Has been found to induce apoptosis and act as an anticancer agent. Ingenol derivatives have received constant and multidisciplinary attention on account of their pleiotropic pattern of biological activity. This includes activation of PKC (protein kinase C), tumor-promotion, anticancer, and anti-HIV properties, and the possibility of dissecting co-cancerogenic and clinically useful activities has been demonstrated. Certain ingenol esters show powerful anticancer activity, and a structure-activity relationship model to discriminate between their apoptotic and non-apoptotic properties has been developed. Ingenol is an activator of PKC ε and PKC δ.


References

1. Hasler, C.M., et al. 1992. Cancer Res. 52: 202-208. PMID: 1727380
2. Armstrong, S. and Gonote, C.E. 1994. Cardiovasc. Res. 28: 1700-1706. PMID: 7842465
3. Kuwajima, I. and Tanino, K. 2005. Chem. Rev. 105: 4661-4670. PMID: 16351057

Physical State :
Solid
Solubility :
Soluble in DMSO, ethanol, water (partly), hexane, and chloroform (10 mg/ml).
Storage :
Store at 4° C
Melting Point :
213.18° C (Predicted)
Boiling Point :
523.79° C at 760 mmHg (Predicted)
Density :
1.34 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
Ki Data :
PKC: Ki= 30 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
442042
MDL Number :
MFCD00056380
SMILES :
C[C@@H]1C[C@@H]2[C@@H](C2(C)C)[C@@H]3C=C([C@H]([C@]4([C@@]1(C3=O)C=C([C@@H]4O)C)O)O)CO

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Certificate of Analysis

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Ingenol  Product Citations

See how others have used Ingenol. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26151856  Nothias-Scaglia, LF. et al. 2015. Fitoterapia. 105: 202-9.

Citations 1 to 1 of 1 total

Hello. What is the expiry date for this product (batch K1811)? Thank you for your answer

Asked by: AnneD
Thank you for your question. Please contact Technical Service for expiration inquiries.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-11

Bom dia Qual é a materia prima usada na produção desta molecula?

Asked by: Euphorbia
Thank you for your question. This chemical, Ingenol: sc-202184, is derived from a natural source Euphorbia sp. Please contact our Technical Service department if you require further assistance.
Answered by: Technical Support
Date published: 2016-10-21
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Rated 5 out of 5 by from Hasler Hasler, CM. et al. (PubMed 1727380) examined the ability of Ingenol to bind to and activate protein kinase C and to induce similar responses to the phorbol esters in biological systems. Their data demonstrated that Ingenol binds to protein kinase C with a Ki of 30 M and activates the enzyme. -SCBT Publication Review
Date published: 2015-04-14
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