IndomethacinAn inhibitor of Cox-1 and activator of PPARγ

Indomethacin (CAS 53-86-1)

Indomethacin | CAS 53-86-1 is rated 5.0 out of 5 by 1.
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Synonym: 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid; Indocin
Application: An inhibitor of Cox-1 and activator of PPARγ
CAS Number: 53-86-1
Purity: ≥99%
Molecular Weight: 357.8
Molecular Formula: C19H16ClNO4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Indomethacin, an antiinflammatory agent, inhibits Cox-1 and Cox-2 (cyclooxygenases) with selectivity for Cox-1 (IC50 of 230 nM) over Cox-2 (IC50 of 630 nM). Additionally, indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis. Other studies show indomethacin to stabilize cholesterol-dependent nanoclusters and enhance phase separation in biological membranes, which could consequentially effect plasma membrane assembled cell signaling cascades. Indomethacin is an activator of PPAR α.


References

1. Salari, H., et al. 1984. Prostaglandins Leukot. Med. 13: 53-60. PMID: 6424136
2. Meade, E.A., et al. 1993. J. Biol. Chem. 268: 6610-6614. PMID: 8454631
3. Lehmann, J.M., et al. 1997. J. Biol. Chem. 272: 3406-3410. PMID: 9013583
4. Zhou, Y., et al. 2010. J. Biol. Chem. [Epub ahead of print]. PMID: 20826816

Physical State :
Solid
Solubility :
Soluble in ethanol (25 mg/ml), DMSO (25 mg/ml) Solutions are yellow in color.
Storage :
Store at room temperature
Melting Point :
155° C
Boiling Point :
~499.4° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3715
MDL Number :
MFCD00057095
EC Number :
200-186-5
SMILES :
CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

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Indomethacin  Product Citations

See how others have used Indomethacin. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 30664786  Liu, PH.|Shah, RB.|Li, Y.|Arora, A.|Ung, PM.|Raman, R.|Gorbatenko, A.|Kozono, S.|Zhou, XZ.|Brechin, V.|Barbaro, JM.|Thompson, R.|White, RM.|Aguirre-Ghiso, JA.|Heymach, JV.|Lu, KP.|Silva, JM.|Panageas, KS.|Schlessinger, A.|Maki, RG.|Skinner, HD.|de Stanchina, E.|Sidi, S.| et al. 2019. Nat. Cell Biol.

PMID: # 30060502  Grossini, E. et al. 2018. Nutrients. 10:

PMID: # 28739698  Park, Y.|Son, JY.|Lee, BM.|Kim, HS.|Yoon, S.| et al. 2017. Anticancer Res. 37: 4139-4146.

PMID: # 26679930  Gökçinar-Yagci, B. et al. 2015. Cell and tissue banking.

PMID: # 25204503  Teklemariam, T. et al. 2014. Biochemical and biophysical research communications. 452: 753-9.

PMID: # 25159063  Gadkari, R. et al. 2014. Regenerative medicine. 9: 453-65.

Citations 1 to 6 of 6 total

What is the shelf life of this chemical? We have lot # J2815 with an manufacture date of 11/28/2014. What is the expiration date for this lot?

Asked by: CL Goodman
All of our products are warrantied for one year from the date purchased. If a CoA with an expiration date is needed, please inquire with Technical Service and one will be provided to you. Please note that all CoAs are lot-specific.
Answered by: Tech Service
Date published: 2019-04-09

What is the appearance of the compound?

Asked by: two2igm05
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Answered by: Tech Service 8
Date published: 2017-01-20
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Rated 5 out of 5 by from Zou et al Zou et al. (PubMed ID 20826816) showed that the PPARgamma activator, Indomethacin, potentiated cholesterol-dependent nanoclustering and phase separation of cell plasma membranes. -SCBT Publication Review
Date published: 2015-04-16
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