INDO 1/AMA cell permeable derivative of INDO 1

INDO 1/AM (CAS 112926-02-0)

INDO 1/AM | CAS 112926-02-0 is rated 5.0 out of 5 by 2.
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Synonym: Indo-1 pentaacetoxymethyl ester; Indo 1-AM
Application: A cell permeable derivative of INDO 1
CAS Number: 112926-02-0
Molecular Weight: 1009.91
Molecular Formula: C47H51N3O22
* Refer to Certificate of Analysis for lot specific data (including water content).
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INDO 1/AM is a cell-permeable ester derivative of INDO 1. After crossing the cell membrane, INDO 1/AM is rapidly hydrolyzed by cytoplasmic esterases and remains trapped within the cell. INDO 1/AM has been used to selectively monitor Ca2+ levels in mitochondria and in the cytosol.


References

1. Lopez, M., et al. 1989. Cytometry. 10: 165-173. PMID: 2540938
2. Grierson, J.P., et al. 1992. J. Neurophysiol. 67: 704-714. PMID: 1315847
3. Griffiths, E.J., et al. 1997. Am. J. Physiol. 273: C37-C44. PMID: 9252440
4. Zhou, Z., et al. 1998. J. Physiol. 507: 379-403. PMID: 9518700

Physical State :
Solid
Solubility :
Soluble in acetonitrile (10 mg/ml), and DMSO.
Storage :
Store at -20° C
Boiling Point :
1009.2° C at 760 mmHg (Predicted)
Density :
1.38 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
Fluoresence :
λex 330 nm, λem 450 nm in with Calcium; λex 356 nm, λem 478 nm in methanol
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
123918
MDL Number :
MFCD00036955
SMILES :
CC1=CC(=C(C=C1)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)OCCOC2=C(C=CC(=C2)C3=CC4=C(N3)C=C(C=C4)C(=O)OCOC(=O)C)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Works great for general calcium staining Works great for general calcium staining. Highly recommended.
Date published: 2017-12-15
Rated 5 out of 5 by from Lopez et al Lopez et al. (PubMed ID 2540938) found that INDO 1/AM increased cytosolic-free calcium levels (Ca2+i) in polymorphonuclear leukocytes. -SCBT Publication Review
Date published: 2015-02-28
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