Indirubin Derivative E804 (CAS 854171-35-0)
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Indirubin Derivative E804, a synthetic member of the indirubin family known for its diverse biological actions, has attracted interest in scientific investigations for its notable properties. This compound, developed to enhance the attributes of indirubin derivatives, has been primarily explored for its potential ability to combat cancer. It exhibits strong anti-cancer capabilities by hindering cell growth, promoting programmed cell death, and reducing tumor development across various cancer types, including leukemia, colorectal, and breast cancer in vitro. Beyond its anti-cancer potential, Indirubin Derivative E804 also displays significant effects in modulating immune responses and reducing inflammation. Its effectiveness is attributed to its interaction with cellular molecular targets, affecting critical pathways related to cell growth, death, and inflammation, such as the inhibition of cyclin-dependent kinases and glycogen synthase kinase-3β.
Indirubin Derivative E804 (CAS 854171-35-0) References
- Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells. | Nam, S., et al. 2005. Proc Natl Acad Sci U S A. 102: 5998-6003. PMID: 15837920
- Attenuation of psoriasis-like skin lesion in a mouse model by topical treatment with indirubin and its derivative E804. | Miyoshi, K., et al. 2012. J Dermatol Sci. 65: 70-2. PMID: 22051056
- An indirubin derivative, E804, exhibits potent angiosuppressive activity. | Chan, YK., et al. 2012. Biochem Pharmacol. 83: 598-607. PMID: 22178720
- Indirubin derivative E804 inhibits angiogenesis. | Shin, EK. and Kim, JK. 2012. BMC Cancer. 12: 164. PMID: 22554053
- Indirubin-3'-(2,3 dihydroxypropyl)-oximether (E804) is a potent modulator of LPS-stimulated macrophage functions. | Babcock, AS., et al. 2013. Toxicol Appl Pharmacol. 266: 157-66. PMID: 23107598
- Physicochemical characterization and in vitro permeation of an indirubin derivative. | Heshmati, N., et al. 2013. Eur J Pharm Sci. 50: 467-75. PMID: 23994641
- Anti-inflammatory and antiviral effects of indirubin derivatives in influenza A (H5N1) virus infected primary human peripheral blood-derived macrophages and alveolar epithelial cells. | Mok, CK., et al. 2014. Antiviral Res. 106: 95-104. PMID: 24717263
- E804 induces growth arrest, differentiation and apoptosis of glioblastoma cells by blocking Stat3 signaling. | Zhang, Y., et al. 2015. J Neurooncol. 125: 265-75. PMID: 26386687
- Anti-inflammatory effects of indirubin derivatives on influenza A virus-infected human pulmonary microvascular endothelial cells. | Kwok, HH., et al. 2016. Sci Rep. 6: 18941. PMID: 26732368
- pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs. | Gerlach, T., et al. 2017. J Virol. 91: PMID: 28356532
- Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice. | Chen, L., et al. 2017. Front Mol Neurosci. 10: 393. PMID: 29234273
- Modulation of glioma-inflammation crosstalk profiles in human glioblastoma cells by indirubin-3'-(2,3 dihydroxypropyl)-oximether (E804) and 7-bromoindirubin-3'-oxime (7BIO). | Scobie, MR., et al. 2019. Chem Biol Interact. 312: 108816. PMID: 31505164
- Evaluation of the Developmental Toxicity Induced by E804 in Zebrafish Embryos. | Wang, R., et al. 2020. Front Pharmacol. 11: 32. PMID: 32116709
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Indirubin Derivative E804, 1 mg | sc-221751 | 1 mg | $204.00 |