Indirubin-3'-monoxime is a potent inhibitor of GSK-3β (IC50=22 nM)1. Indirubin-3'-monoxime also inhibits CDK1 (p34cdc2; IC50=180 nM) and CDK5 (IC50=100 nM)1. Indirubin-3'-monoxime reversibly arrests asynchronous HBL-100 cells at G22. This compound induces apoptosis in the mammary carcinoma cell line MCF-7 (10 µM). Indirubin-3'-monoxime is an inhibitor of Cdk2, cyclin A, cyclin B, cyclin E and p35.
1. Leclerc, S., et al. 2001. J. Biol. Chem. 276: 251-260. PMID: 11013232
Soluble in DMSO (6 mg/ml), ethanol (4 mg/ml), DMF (~10 mg/ml), 1:5 DMSO:PBS (pH 7.2) (0.15 mg/ml), and methanol. Insoluble in water.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Lee JJ; et alLee JJ; et al. (PubMed ID: 25451564) determined that Indirubin-3'-monoxime inhibited collagen-induced platelet aggregation by suppressing phospholipase C 2 (PLC 2) phosphorylation, in rat carotid artery injury model. -SCBT Publication Review
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