IMS2186An anti-prileferative and anti-angiogenic compound

IMS2186 (CAS 1031206-36-6)

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Synonym: 3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one
Application: An anti-prileferative and anti-angiogenic compound
CAS Number: 1031206-36-6
Molecular Weight: 296.32
Molecular Formula: C18H16O4
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An anti-proliferative and anti-angiogenic compound. IMS2186 is a novel synthetic compound developed as an anti-CNV drug. The proposed mechanism of action under investigation, is blocking the cell cycle at G2 and inhibiting the production of PGE2/TNF-α. The latter contributing to anti-angiogenic and antiinflammatory effects. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC50= 0.1 µM) and cell migration, which plays a role in many biological processes: inflammation, angiogenesis, and scar formation. The physicochemical structure of IMS2186 showed also that the free drug concentration in a physiological media (e.g., vitreous or saline) is 8-10 µM above the IC50 for all these activities (0.1-3.0 µM). Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss.


References

Falkenstein, I.A., et al., Toxicity and intraocular properties of a novel long-acting anti-proliferative and anti-angiogenic compound IMS2186. Curr. Eye Res. 33, 599-609, (2008)

Physical State :
Solid
Solubility :
Soluble in DMSO: >20 mg/mL
Storage :
Desiccate at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
24987039
SMILES :
CC1=CC2=C(C=C1)OC/C(=C\\C3=CC(=C(C=C3)OC)O)/C2=O

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