ImperatorinA useful furocoumarin and phytochemical

Imperatorin (CAS 482-44-0)

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Synonym: Ammidin; Marmelide; Marmelosin
Application: A useful furocoumarin and phytochemical
CAS Number: 482-44-0
Molecular Weight: 270.28
Molecular Formula: C16H14O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also suggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been suggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway.


References

1. Pae, H.O., et al. 2002. Pharmacol. Toxicol. 91: 40-48. PMID: 12193260
2. Sancho, R., et al. 2004. J. Biol. Chem. 279: 37349-37359. PMID: 15218031

Physical State :
Solid
Solubility :
Soluble in DMSO (≥5 mg/ml), methanol, DMF, and water (slightly). Insoluble in ethanol.
Storage :
Store at -20° C
Melting Point :
102° C
Boiling Point :
~448.3° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
BACE: IC50 = 30.5 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
LV1575000
PubChem CID :
10212
Merck Index :
14: 4925
MDL Number :
MFCD00016881
EC Number :
207-581-1
Beilstein Registry :
249728
SMILES :
CC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C

Download SDS (MSDS)

Certificate of Analysis

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