Imiquimod is a derivative of imidazoquinolinamine that inhibits angiogenesis and is an immune response modifier. Studies have reported that Imiquimod has the ability to downregulate metastasis and induce alpha-interferon (IFN-α). Additionally, Imiquimod is a TLR7 (toll-like receptor 7) agonist which induces plasmacytoid dendritic cell (pDC) maturation. Imiquimod acts on dendritic cells expressing TLR7, and induces an immune response. Nuclear factor-B helps mediate the activity of Imiquimod, and is involved in increasing chemokine and cytokine levels. The antiangiogenic property of Imiquimod has been shown to be mediated by IL-18. Research shows that Imiquimod can induce apoptosis in cancer cells. Also suggested to be an activator of caspase-3 and NFκB.
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See how others have used Imiquimod. Click on the entry to view the PubMed entry .
PMID: # 26462419 Wu, V. et al. 2016. Mucosal immunology. 9: 777-86.
PMID: # 25767074 Li, ZJ. et al. 2015. Biochem. Biophys. Res. Commun. 459: 673-8.
PMID: # 24743316 Sohn, KC. et al. 2014. PloS one. 9: e95337.
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