Imipramine-d6An inhibitor of ST and SLC6A2, but not the dopamine transporter

Imipramine-d6 (CAS 65100-45-0)

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Synonym: 10,11-Dihydro-N,N-di(methyl-d3)-5H-dibenz[b,f]azepine-5-propanamine
Application: An inhibitor of ST and SLC6A2, but not the dopamine transporter
CAS Number: 65100-45-0
Molecular Weight: 286.44
Molecular Formula: C19H18D6N2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Imipramine-d6, a labeled tricyclic antidepressant that inhibits the serotonin and norepinephrine transporters (ST and SLC6A2), but has little effect on the dopamine transporter. Additionally, imipramine-d6 can inhibit mAChR M2, SR-2A and SR-2C.


References

1. Checkley, S A., et al., 1981. A pilot study of the mechanism of action of desipramine. The British journal of psychiatry : the journal of mental science. 138(): 248-51. PMID: 6268238
2. Zhu, M Y., et al., 1998. Down-regulation of the human norepinephrine transporter in intact 293-hNET cells exposed to desipramine. Journal of neurochemistry. 70(4): 1547-55. PMID: 9523572
3. Okugawa, G., et al., 1999. Long-term treatment with antidepressants increases glucocorticoid receptor binding and gene expression in cultured rat hippocampal neurones. Journal of neuroendocrinology. 11(11): 887-95. PMID: 10520140
4. Torres, Gonzalo E., et al., 2003. Plasma membrane monoamine transporters: structure, regulation and function. Nature reviews. Neuroscience. 4(1): 13-25. PMID: 12511858
5. KLERMAN, G L., et al., 1965. CLINICAL PHARMACOLOGY OF IMIPRAMINE AND RELATED ANTIDEPRESSANT COMPOUNDS. Pharmacological reviews. 17(): 101-41. PMID: 14294030

Appearance :
Oil
Solubility :
Soluble in Chloroform, Dichloromethane, and Ethyl Acetate
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
45039560
SMILES :
[2H]C([2H])([2H])N(CCCN1C2=C(CCC3=C1C=CC=C3)C=CC=C2)C([2H])([2H])[2H]

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Certificate of Analysis

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