IMD 0354A selective IKK beta (IKK-2) inhibitor

IMD 0354 (CAS 978-62-1)

IMD 0354 | CAS 978-62-1 is rated 4.0 out of 5 by 1.
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Synonym: IKK-2 Inhibitor V
Application: A selective IKK beta (IKK-2) inhibitor
CAS Number: 978-62-1
Purity: ≥95%
Molecular Weight: 383.68
Molecular Formula: C15H8ClF6NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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IMD 0354 is a cell-permeable salicylamide compound shown to act as a selective IKK β (IKK-2) inhibitor by blocking IκBα phosphorylation and preventing induction of NF-κB p65 nuclear translocation. Found to reduce IL-1β and MCP-1 production in cardiac muscle cells and thus act as a cardioprotectant. IMD 0354 is also shown to improve insulin resistance in KKAγ mice through regulation of adiponectin release.


References

1. Kamon, J., et al. 2004. Biochem. Biophys. Res. Commun. 323: 242-248. PMID: 15351728
2. Onai, Y., et al. 2004. Cardiovasc. Res. 63: 51-59. PMID: 15194461
3. Tanaka, A., et al. 2005. Blood. 105: 2324-2331. PMID: 15561889

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), ethanol (100 mM), and water (<1 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
184.03° C (Predicted)
Boiling Point :
323.15° C at 760 mmHg (Predicted)
Density :
1.56 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
IC50 :
IKK-2 : IC50 = 250 nM; IL-1β and MCP-1 production: IC50 = <1 µM
Ki Data :
Flt-3/Flk-2: Ki= 0.79 µM (human); PKC γ: Ki= >7.94 µM (human); PKC δ: Ki= >7.94 µM (human); Chk1: Ki= >7.94 µM (human); Cdc2 p34: Ki= >7.94 µM (human)
pK Values :
pKa: 7.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5081913
MDL Number :
MFCD00218820
SMILES :
C1=CC(=C(C=C1Cl)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 4 out of 5 by from A decrease in cyclin D3 protein expression A decrease in cyclin D3 protein expression observed by WB in MDA-MB-231 cells post treatment with IMD 0354. -SCBT QC
Date published: 2015-03-22
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