Illudin S is potent antitumor sesquiterpene, first isolated from the fungus, Clitocybe illudens, in 1963. Illudin S is metabolically activated to reactive intermediates that bind DNA. The DNA damage appears to differ from that of other reactive metabolites. Importantly, illudin S exhibits in vitro and in vivo potency against multi-drug resistant tumours.
Soluble in ethanol, methanol, DMSO, DMF, and water (limited).
Store at -20° C
171.93° C (Predicted)
~509.6° C at 760 mmHg (Predicted)
~1.3 g/cm3 (Predicted)
n20D 1.62 (Predicted)
HL-60: IC50 = 3 nM (human)
pKa: 12.5 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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