IKK Inhibitor XA potent, ATP-competitive, and reversible inhibitor of IKK

IKK Inhibitor X

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Application: A potent, ATP-competitive, and reversible inhibitor of IKK
Purity: ≥98%
Molecular Weight: 322.8
Molecular Formula: C17H11ClN4O
* Refer to Certificate of Analysis for lot specific data (including water content).
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IKK Inhibitor X is a cell-permeable β-carboline compound that exhibits anti-inflammatory properties. A potent, ATP-competitive, and reversible inhibitor of IKK.


References

Catley, M.C., et al. 2006. Mol. Pharmacol. 70, 697. Wen, D., et al. 2006. J. Pharm. Exp. Ther. 317, 989. Castro, A.C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 2419. Hideshima, T., et al. 2002. J. Biol. Chem. 277, 16639.

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mg/ml).
Storage :
Store at 4° C
Density :
~1.51 g/cm3 (Predicted)
Refractive Index :
n20D ~1.81 (Predicted)
IC50 :
IKK: IC50 = 88 nM; NF-κB activation: EC5050 = 5 µM (TNF-α-treated HeLa cells)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9949093
SMILES :
C1=CC(=CN=C1)C(=O)NC2=C3C(=CC(=C2)Cl)C4=C(N3)C=NC=C4

Download SDS (MSDS)

Certificate of Analysis

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