IGF-1R Inhibitor, PPPA non-competitive inhibitor of IGF-1R but not IR

IGF-1R Inhibitor, PPP (CAS 477-47-4)

IGF-1R Inhibitor, PPP | CAS 477-47-4 is rated 5.0 out of 5 by 1.
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Synonym: Picropodophyllin
Application: A non-competitive inhibitor of IGF-1R but not IR
CAS Number: 477-47-4
Purity: ≥96%
Molecular Weight: 414.4
Molecular Formula: C22H22O8
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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IGF-1R Inhibitor, PPP is an insulin-like, cell-permeable cis-cyclolignan compound that acts as a non-competitive, potent, and specific inhibitor of growth factor-I receptor kinase (IGF-1R; IC50 = 1 nM in cell-free kinase assay; ≤ 60 nM for cell viability and receptor autophosphorylation in melanoma cell lines). IGF-1R Inhibitor, PPP exhibits little effect towards IR, FGFR, PDGFR and EGFR, and exerts no effects on microtubules and DNA topoisomerase II. This product is the first inhibitor reported to discriminate between IGF-1R and IR, and has shown complete inhibition of IGF-1R-dependent tumor cell growth at 20 mg/kg/12 hr i.p. with minimum toxic effect.


References

1. Girnita, A., et al. 2004. Cancer Res. 64: 236-242. PMID: 14729630

2. Strömberg, T., et al. 2006. Blood. 107: 669-678. PMID: 16166596

3. Guha, M., et al. 2007. J. Biol. Chem. 282: 14536-14546. PMID: 17355970

4. Economou, M.A., et al. 2008. Invest. Ophthalmol. Vis. Sci. 49: 2620-2626. PMID: 1851559

Usage :
Store solutions at 4°C. For long term storage prepare aliquots and store at -20°C.
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (5 mM).
Storage :
Store at 4° C
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
IGF1R autophosphorylation: IC50 = ~ 1 nM; HT-29: IC50 = 60 nM (human); A549: IC50 = 60 nM (human); P388: IC50 = 60 nM (mouse)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
LV2510000
PubChem CID :
72435
Merck Index :
14: 7546
SMILES :
COC1=CC(=CC(=C1OC)OC)[C@H]2[C@H]3[C@H](COC3=O)[C@H](C4=CC5=C(C=C24)OCO5)O

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Certificate of Analysis

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IGF-1R Inhibitor, PPP  Product Citations

See how others have used IGF-1R Inhibitor, PPP. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 47 total

PMID: # 31081524  Son, JW.|Park, J.|Kim, YE.|Ha, J.|Park, DW.|Chang, MS.|Koh, SH.| et al. 2019. Mol. Neurobiol.

PMID: # 31002310  Chesnokova, V. et al. 2019. Endocrinology. 160: 1439-1447.

PMID: # 30911300  Aboalola, D.|Han, VKM.| et al. 2019. Stem Cells Int. 2019: 9245938.

PMID: # 30636901  Hwang, DH.|Park, HH.|Shin, HY.|Cui, Y.|Kim, BG.| et al. 2018. Exp Neurobiol. 27: 489-507.

PMID: # 29363790  Rodriguez-Monterrosas, C. et al. 2018. J. Cell. Biochem. 119: 5413-5425.

PMID: # 30521580  Shastri, AA.|Hegde, V.|Peddibhotla, S.|Feizy, Z.|Dhurandhar, NV.| et al. 2018. PLoS ONE. 13: e0208427.

PMID: # 29248598  Shuang, T.|Fu, M.|Yang, G.|Wu, L.|Wang, R.| et al. 2018. Biochem. Pharmacol. 149: 143-152.

PMID: # 29236310  Rodriguez-Monterrosas, C. et al. 2018. J. Cell. Biochem. 119: 4061-4071.

PMID: # 28302721  Fujiki, K.|Inamura, H.|Miyayama, T.|Matsuoka, M.| et al. 2017. J. Biol. Chem. 292: 7942-7953.

PMID: # 28389629  Xu, X.|Sun, J.|Song, R.|Doscas, ME.|Williamson, AJ.|Zhou, J.|Sun, J.|Jiao, X.|Liu, X.|Li, Y.| et al. 2017. Oncotarget. 8: 30438-30454.

Citations 1 to 10 of 47 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. IGF-1R Inhibitor, PPP, sc-204008, is in white powder form.
Answered by: Chemical Support 4
Date published: 2017-04-25

Does sc-204008 contain any biological? In other words, it is derived from living organisms?

Asked by: ChemSynth123
Thank you for your question. IGF-1R Inhibitor, PPP (CAS 477-47-4); sc-204008 is derived from a synthetic source and contains no biological substance.
Answered by: Chemical Support 7
Date published: 2017-03-01
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Rated 5 out of 5 by from Othman Othman, E.M. et al. (PubMed 24355212) used product sc-204008 (IGF-1R Inhibitor) to determine if the signaling pathway of insulin-mediated genotoxicity begins with activation of IGF-1R. In the presence of sc-204008 genomic damage was significantly reduced in a hyperinsulinemia environment. -SCBT Publication Review
Date published: 2015-07-02
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