IdoxuridineA cytotoxic analog of thymidine, antiviral

Idoxuridine (CAS 54-42-2)

Idoxuridine | CAS 54-42-2 is rated 5.0 out of 5 by 1.
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Synonym: 5-Iodo-2′-deoxyuridine; 1-(2-Deoxy-β-D-ribofuranosyl)-5-iodouracil; 5-IUdR
Application: A cytotoxic analog of thymidine, antiviral
CAS Number: 54-42-2
Purity: ≥98%
Molecular Weight: 354.10
Molecular Formula: C9H11IN2O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Idoxuridine is a cytotoxic, anti-viral thymidine analog.


References

Pressacco, J., Hedley, D.W., Erlichman, C. Cancer Res. 54:3772-3778 (1994). Teicher, B.A., Alvarez Sotomayor, E. In "Cancer Chemotherapeutic Agents" Foye, W.O. (Ed.) ACS Professional Reference, pp. 515-516, 1995.

Physical State :
Solid
Solubility :
Soluble in water (2 mg/ml), 1 N ammonium hydroxide (50 mg/ml), acetone (1.6 mg/ml), methanol (4.4 mg/ml), and alcohol (2.6 mg/ml).
Storage :
Store at 4° C
Melting Point :
194° C (lit.)
Density :
~2.1 g/cm3 (Predicted)
Refractive Index :
n20D ~1.72 (Predicted)
Optical Activity :
α20/D +29.5°±1.5°, c = 1 in 1mol/l NaOH
IC50 :
PRK cell line: IC50 = 0.1 ug.mL-1; HEL: IC50 = 0.17 ug.mL-1 (human)
Ki Data :
Thymidine kinase, cytosolic: Ki= 90 nM (human); Herpesvirus 1: Ki= 400 nM (human); Herpesvirus 2: Ki= 3.98 µM (human)
pK Values :
pKa: 7.94 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
YU7700000
PubChem CID :
5905
Merck Index :
14: 4891
MDL Number :
MFCD00134656
EC Number :
200-207-8
Beilstein Registry :
30397
SMILES :
C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)I)CO)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Various publications cite the use of Idoxuridine Various publications cite the use of Idoxuridine, a cytotoxic analog of thymidine, as an antiviral. -SCBT Publication Review
Date published: 2015-02-18
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