Idarubicin Hydrochloride CAS: 57852-57-0
MF: C26H27NO9•HCl
MW: 533.95
Idarubicin Hydrochloride is an apoptosis inducer.

Idarubicin Hydrochloride (CAS 57852-57-0)

Idarubicin Hydrochloride | CAS 57852-57-0 is rated 5.0 out of 5 by 2.
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Alternate Names: 4-Demethoxydaunorubicin; Zavedos
Application: Idarubicin Hydrochloride is an apoptosis inducer
CAS Number: 57852-57-0
Purity: ≥98%
Molecular Weight: 533.95
Molecular Formula: C26H27NO9•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Idarubicin Hydrochloride is the hydrochloride salt preparation of Idarubicin (IDA), an anthracycline and an analog of daunorubicin (sc-218089). IDA is rapidly metabolized to its 13-dihydroderivative (Idarubicinol) which is more stable than the parent form. This compound has been reported to trigger apoptotic cell death via enhancement of Fas and caspase-3/caspase-7 expression. In experiments, where cells were exposed to IDA, reactive oxygen species (ROS) were produced which induced DNA strand breaks and prevented DNA polymerase reaction. Idarubicin Hydrochloride is an inhibitor of Topo II α. Idarubicin Hydrochloride is also a substrate of CYP2D6 and CYP2C9.


References

1. Ganzina, F., et al. 1986. Invest New Drugs. 4: 85-105. PMID: 3516918

2. Tsuruo, T., et al. 1993. Anticancer Res. 13: 357-361. PMID: 8517647

3. Fukushima, T., et al. 1993. Int. J. Hematol. 57: 121-130. PMID: 8494991

4. Belaud-Rotureau, M.A., et al. 2000. Leukemia. 14: 1266-1275. PMID: 10914552

5. Marczak, A. and Jóźwiak, Z. 2009. Toxicol In Vitro. 23: 1188-1194. PMID: 19490936

Appearance :
Crystalline powder
Physical State :
Solid
Derived From :
Synthetic
Solubility :
Soluble in DMSO (107 mg/ml at 25° C), water (10 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), and methanol (20 mg/ml).
Storage :
Store at -20° C
Melting Point :
183-185° C
Refractive Index :
n20D 1.71 (Predicted)
Optical Activity :
α20D +184, c = 0.1 in methanol
IC50 :
Plasmodium falciparum: IC50 = 1 nM; K562: IC50 = 2 nM (human); Jurkat: IC50 = 3.35 µM (human); Mycobacterium smegmatis: IC50 = 3.61 µM; HepG2: IC50 = 12.3 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
HB7877000
PubChem CID :
Merck Index :
14: 4886
MDL Number :
MFCD00866457
EC Number :
260-990-7
SMILES :
C[[email protected]]1[[email protected]]([[email protected]](C[[email protected]@H](O1)O[[email protected]]2C[[email protected]@](CC3=C2C(=C4C(=C3O)C(=O)C5=CC=CC=C5C4=O)O)(C(=O)C)O)N)O.Cl

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Certificate of Analysis

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Idarubicin Hydrochloride (CAS 57852-57-0)  Product Citations

See how others have used Idarubicin Hydrochloride (CAS 57852-57-0). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 32554494  Proc. Natl. Acad. Sci. U.S.A.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Great feature We bought this product a few weeks ago and it worked nicely in our tissue culture experiments!
Date published: 2018-08-13
Rated 5 out of 5 by from Ristic Ristic, B. et al. (PubMed 24907655) reported that Idarubicin Hydrochloride induces mTOR-dependent cytotoxic autophagy in leukemic cells. -SCBT Publication Review
Date published: 2015-06-21
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