Idarubicin HydrochlorideAn apoptosis inducer

Idarubicin Hydrochloride (CAS 57852-57-0)

Idarubicin Hydrochloride | CAS 57852-57-0 is rated 5.0 out of 5 by 2.
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Synonym: 4-Demethoxydaunorubicin; Zavedos
Application: An apoptosis inducer
CAS Number: 57852-57-0
Purity: ≥98%
Molecular Weight: 533.95
Molecular Formula: C26H27NO9•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Idarubicin Hydrochloride is the hydrochloride salt preparation of Idarubicin (IDA), an anthracycline and an analog of daunorubicin (sc-218089). IDA is rapidly metabolized to its 13-dihydroderivative (Idarubicinol) which is more stable than the parent form. This compound has been reported to trigger apoptotic cell death via enhancement of Fas and caspase-3/caspase-7 expression. In experiments, where cells were exposed to IDA, reactive oxygen species (ROS) were produced which induced DNA strand breaks and prevented DNA polymerase reaction. Idarubicin Hydrochloride is an inhibitor of Topo II α. Idarubicin Hydrochloride is also a substrate of CYP2D6 and CYP2C9.


References

1. Ganzina, F., et al. 1986. Invest New Drugs. 4: 85-105. PMID: 3516918
2. Tsuruo, T., et al. 1993. Anticancer Res. 13: 357-361. PMID: 8517647
3. Fukushima, T., et al. 1993. Int. J. Hematol. 57: 121-130. PMID: 8494991
4. Belaud-Rotureau, M.A., et al. 2000. Leukemia. 14: 1266-1275. PMID: 10914552
5. Marczak, A. and Jóźwiak, Z. 2009. Toxicol In Vitro. 23: 1188-1194. PMID: 19490936

Appearance :
Crystalline powder
Physical State :
Solid
Derived From :
Synthetic
Solubility :
Soluble in water or methanol
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
636362
MDL Number :
MFCD00866457
EC Number :
260-990-7
SMILES :
CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=CC=CC=C5C4=O)O)(C(=O)C)O)N)O.Cl

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Certificate of Analysis

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Rated 5 out of 5 by from Great feature We bought this product a few weeks ago and it worked nicely in our tissue culture experiments!
Date published: 2018-08-13
Rated 5 out of 5 by from Ristic Ristic, B. et al. (PubMed 24907655) reported that Idarubicin Hydrochloride induces mTOR-dependent cytotoxic autophagy in leukemic cells. -SCBT Publication Review
Date published: 2015-06-21
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