Icilin is a small molecule agonist of the TRPM8 (transient receptor potential M8) ion channel, a non-selective Ca2+ channel which depolarizes somatosensory neurons in response to cold temperature. Though Icilin is structurally unrelated to Menthol (sc-202705), both compounds activate the TRPM8 receptor to produce cold sensation, and Icilin is ~200-fold more potent than Menthol in this action. Sensitization of TRPM8 by Icilin exhibits a significant temporal delay and a dependence upon extracellular Ca2+, disparate from the immediately-activating, Ca2+ independent action of Menthol. This variable sensitization of the TRPM8 indicates a unique modular activation mechanism depending on the presence of co-agonist input, and Icilin has been employed as a tool for elucidation of TRP ion channel functionality. Icilin regulates Na+ homeostasis in cells across the epithelia through the amiloride-sensitive epithelial Na+ channel. Icilin is an activator of ANKTM1. Icilin is a inhibitor of TRPV3.
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See how others have used Icilin (CAS 36945-98-9). Click on the entry to view the PubMed entry .
PMID: # 18802106 Prasad, P. et al. 2008. J. Immunol. 181: 5024-5034.
PMID: # 15363396 Chuang, HH. et al. 2004. Neuron. 43: 859-869.
PMID: # 32224140 Biochem. Pharmacol. 177: 113936.
PMID: # 31654626 Biochem. Pharmacol. 113678.
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