IbuprofenA Cox-1 and Cox-2 inhibitor

Ibuprofen (CAS 1189866-35-0 (unlabeled))

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Synonym: 2-[4-(2-methylpropyl)phenyl]propanoic acid; alpha-Methyl-4-(isobutyl)phenylacetic acid; p-Isobutylhydratropic acid
Application: A Cox-1 and Cox-2 inhibitor
CAS Number: 1189866-35-0 (unlabeled)
Purity: ≥99%
Molecular Weight: 206.28
Molecular Formula: C13H18O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ibuprofen inhibits Cox (cyclooxygenase) selectively, targeting Cox-1 (PGH synthase-1) with an IC50 of 13 μM, and Cox-2 (PGH synthase-2) with an IC50 of 370 μM. Ibuprofen is useful as a nonsteroidal anti-inflammatory research chemical. Ibuprofen is reported to inhibit the netrophil-dependent edema response of rabbit skin to C5a/PGE23.


References

1. Myers, R.F., et al. 1983. Biochem. Biophys. Res. Commun. 112: 586-592. PMID: 6221723
2. Meade, E.A., et al. 1993. J. Biol. Chem. 268: 6610-6614. PMID: 8454631
3. Rampart, M., et al. 1986. Biochem. Pharmacol. 35: 581-586. PMID: 3081008

Physical State :
Solid
Solubility :
Soluble in ethanol (25 mg/ml), chloroform (1:1), ether (1:2), acetone (1:1.5), aqueous solutions of alkali hydroxides and carbonates, dichloromethane, methanol (50 mg/ml), and ethyl acetate. Insoluble in water.
Storage :
Store at room temperature
Melting Point :
77-78° C
Boiling Point :
~319.6° C (lit.) at 760 mmHg (Predicted)
Density :
~1.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.52
IC50 :
COX-1: IC50 = 2.6 µM (human); COX-2: IC50 = 1.5 µM (human); COX-1: IC50 = 2.9 µM (Ovis aries); COX-2: IC50 = 1.1 µM (Ovis aries)
Ki Data :
COX-1: Ki= 9 µM (ovine); COX-2: Ki= 9 µM (ovine); Solute carrier family 22 member 20: Ki= 1.1 µM (Mus musculus); Solute carrier family 22 member 6: Ki= 4.7 µM (Mus musculus)
pK Values :
pKa: 5.2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
MU6640000
PubChem CID :
3672
Merck Index :
14: 4881
MDL Number :
MFCD00010393
EC Number :
239-784-6
SMILES :
CC(C)CC1=CC=C(C=C1)C(C)C(O)=O

Download SDS (MSDS)

Certificate of Analysis

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What is the solubility of Ibuprofen in toluene?

Asked by: Bala
Thank you for your question. This chemical, Ibuprofen: sc-200534 is soluble in ethanol (25 mg/ml), chloroform (1:1), ether (1:2), acetone (1:1.5), aqueous solutions of alkali hydroxides and carbonates, dichloromethane, methanol (50 mg/ml), and ethyl acetate. Insoluble in water. We do not have any solubility information about toluene.
Answered by: Technical Support
Date published: 2019-01-28

Quelle est la solubilité de l'ibuprofène ? Est-ce qu'il est sous forme liquide ou solide ? Merci

Asked by: Alia11
Merci pour votre question. Ce produit est fourni sous forme solide et est soluble dans l'éthanol (25 mg/ml), chloroforme (1:1), éther (1:2), acétone (1:1.5), solutions aqueuses d'hydroxides alcalins et carbonates, dichlorométhane, méthanol (50 mg/ml), et acétate d'éthyle. C'est un produit non soluble dans l'eau. Thank you for your inquiry. This product is provided as solid form and is soluble in ethanol (25 mg/ml), chloroform (1:1), ether (1:2), acetone (1:1.5), aqueous solutions of alkali hydroxides and carbonates, dichloromethane, methanol (50 mg/ml), and ethyl acetate. Insoluble in water.
Answered by: Technical Support Europe
Date published: 2017-02-09

Is this product soluble in Methanol?

Asked by: hawkeye11
Thank you for your question. Ibuprofen, sc-200534, is soluble in methanol at 50mg/ml.
Answered by: TechService7
Date published: 2016-12-21
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