Ibudilast is a relatively nonselective PDE (phosphodiesterase) inhibitor found to have anti-inflammatory activity primarily targeting the peripheral immune system and in the CNS via attenuation of glial cells. Ibudilast inhibits the aggregation of platelets and acts as a vasodilator by preventing the breakdown of secondary messengers cAMP and cGMP. Ibudilast is an inhibitor of PDE1A, PDE2A, PDE3A, PDE4A and PDE5A.
1. Nishino, K., et al. Jpn. J. Pharmacol. 33: 267-278. PMID: 6193303 2. Souness, J.E., et al. 1994. Br.J.Pharmacol. 111: 1081-1088. PMID: 8032594 3. Kishi, Y., et al. 2001. Cardiovasc. Drug Rev. 19: 215-225. PMID: 11607039
Soluble in DMSO (28 mg/ml), ethanol (100 mM), water (4.5 mg/ml), chloroform, and dichloromethane.
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Coiro P; et alCoiro P; et al. (PubMed ID: 26218293) determined that Ibudilast prevented synaptic and behavioral impairments in maternal immune activation offspring. -SCBT Publication Review
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