IbudilastA nonselective phosphodiesterase inhibitor

Ibudilast (CAS 50847-11-5)

Ibudilast | CAS 50847-11-5 is rated 5.0 out of 5 by 1.
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Application: A nonselective phosphodiesterase inhibitor
CAS Number: 50847-11-5
Purity: >99%
Molecular Weight: 230.31
Molecular Formula: C14H18N2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ibudilast is a relatively nonselective PDE (phosphodiesterase) inhibitor found to have anti-inflammatory activity primarily targeting the peripheral immune system and in the CNS via attenuation of glial cells. Ibudilast inhibits the aggregation of platelets and acts as a vasodilator by preventing the breakdown of secondary messengers cAMP and cGMP. Ibudilast is an inhibitor of PDE1A, PDE2A, PDE3A, PDE4A and PDE5A.


References

1. Nishino, K., et al. Jpn. J. Pharmacol. 33: 267-278. PMID: 6193303
2. Souness, J.E., et al. 1994. Br.J.Pharmacol. 111: 1081-1088. PMID: 8032594
3. Kishi, Y., et al. 2001. Cardiovasc. Drug Rev. 19: 215-225. PMID: 11607039

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in DMSO (28 mg/ml), ethanol (100 mM), water (4.5 mg/ml), chloroform, and dichloromethane.
Storage :
Store at 4° C
Melting Point :
54-58° C
Boiling Point :
175° C at 7.5 mmHg
Density :
1.10 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
Membrane- bound PDE4: IC50 = ~1 µM (guinea pig eosinophils); PDE5A: IC50 = 10 µM; PDE4A: IC50 = 12 µM; PDE2A: IC50 = 35 µM; PDE3A: IC50 = 48 µM; PDE1A: IC50 = 53 µM
pK Values :
pKa: 1.86, pKb: 1.22 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UR0711200
PubChem CID :
3671
Merck Index :
14: 4879
MDL Number :
MFCD00864808
SMILES :
CC(C)C1=NN2C=CC=CC2=C1C(=O)C(C)C

Download SDS (MSDS)

Certificate of Analysis

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Ibudilast  Product Citations

See how others have used Ibudilast. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 21494611  Kiebala, M. et al. 2011. PLoS ONE. 6: e18633.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Coiro P; et al Coiro P; et al. (PubMed ID: 26218293) determined that Ibudilast prevented synaptic and behavioral impairments in maternal immune activation offspring. -SCBT Publication Review
Date published: 2015-04-05
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