IBMXCAS: 28822-58-4
MF: C10H14N4O2
MW: 222.24
A potent inhibitor of phosphodiesterases.

IBMX (CAS 28822-58-4)

IBMX | CAS 28822-58-4 is rated 5.0 out of 5 by 1.
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Synonym: 3-Isobutyl-1-methylanxthine; Methylisobutylxanthine; MIX
Application: A potent inhibitor of phosphodiesterases
CAS Number: 28822-58-4
Purity: ≥99%
Molecular Weight: 222.24
Molecular Formula: C10H14N4O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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IBMX is one of the most potent and nonspecific inhibitors of cyclic nucleotide PDE (phosphodiesterases) with documented IC50 values for PDE1, 2, 3, 4, and 5 equaling 19, 50, 18, 13 and 32. The compound is documented to raise intracellular cyclic AMP levels. In rat sensory neurons the addition of IBMX caused the release of Ca2+ from caffeine ryanodine sensitive internal stores increasing the internal Ca2+ levels and inducing a biphasic membrane current response. Through PDE inhibition IBMX has also inhibited TNFα. IBMX in breast cancer cells has also induced p21 and p27 through a PKA independent pathway. Although a nonspecific PDE inhibitor IBMX does not show inhibition of PDE8B. In neuroendocrine epithelial cells IBMX has been observed to inhibit α-adrenoceptor-mediated 5-HT release at IC50 = 1.3μM.


1. Beavo, J.A., et al. 1970. Mol. Pharmacol. 6: 597-603. PMID: 4322367
2. Usachev, Y., et al. 1995. Pflugers Arch. 430: 420-428. PMID: 7491267
3. Rao, S., et al. 1999. Exp. Cell Res. 252: 211-223. PMID: 10502413
4. Freitag, A., et al. 1998. Eur. J. Pharmacol. 354: 67-71. PMID: 9726632

Physical State :
Solubility :
Soluble in ethanol (10 mg/ml), DMSO(with gentle warming) (1 M), methanol(warm) (50 mg/ml), 2-propanol, dichloromethane, ether, ethyl acetate, and DMF (~5 mg/ml). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
200-201° C (lit.)
Boiling Point :
445.6° C at 760 mmHg (Predicted)
Density :
1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
suppresses α-adrenoceptor-mediated 5-HT release: IC50 = 1.3 µM (neuroendocrine epithelial cells); PDE4: IC50 = 13 µM; PDE3: IC50 = 18 µM; PDE1: IC50 = 19 µM; PDE5 : IC50 = 32 µM; PDE2: IC50 = 50 µM; Phosphodiesterase 1B: IC50 = 100 nM (rat); Sodium channel protein type II alpha subunit: IC50 = 1800 nM (human)
Ki Data :
Adenosine A2b receptor: Ki= 50 nM (rat); Adenosine A2a receptor: Ki= 800 nM (rat); Adenosine A1 receptor: Ki= 2000 nM (rat)
pK Values :
pKa: 8.61 (Predicted), pKb: 1.49 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :
EC Number :
Beilstein Registry :

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IBMX  Product Citations

See how others have used IBMX. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 18 total

PMID: # 31344438  Stathopoulou, K.|Schobesberger, S.|Bork, NI.|Sprenger, JU.|Perera, RK.|Sotoud, H.|Geertz, B.|David, JP.|Christ, T.|Nikolaev, VO.|Cuello, F.| et al. 2019. Cell. Signal. 63: 109362.

PMID: # 31059522  Paul, P.|Ramachandran, S.|Xia, S.|Unruh, JR.|Conkright-Fincham, J.|Li, R.| et al. 2019. PLoS ONE. 14: e0216220.

PMID: # 30755584  Zhao, X.|Wei, S.|Li, Z.|Lin, C.|Zhu, Z.|Sun, D.|Bai, R.|Qian, J.|Gao, X.|Chen, G.|Xu, Z.| et al. 2019. Cell Death Dis. 10: 127.

PMID: # 29879443  Su, S.|Wu, G.|Cheng, X.|Fan, J.|Peng, J.|Su, H.|Xu, Z.|Cao, M.|Long, Z.|Hao, Y.|Li, G.|Li, S.|Hai, C.|Wang, X.| et al. 2018. Free Radic. Biol. Med. 124: 122-134.

PMID: # 29022064  Zhang, QH. et al. 2018. Inflamm. Res. 67: 157-168.

PMID: # 30060630  Han, GE. et al. 2018. Int J Mol Sci. 19:

PMID: # 29593329  Romero, M.|Sabaté-Pérez, A.|Francis, VA.|Castrillón-Rodriguez, I.|Díaz-Ramos, Á.|Sánchez-Feutrie, M.|Durán, X.|Palacín, M.|Moreno-Navarrete, JM.|Gustafson, B.|Hammarstedt, A.|Fernández-Real, JM.|Vendrell, J.|Smith, U.|Zorzano, A.| et al. 2018. Nat. Cell Biol. 20: 443-454.

PMID: # 28730281  Świerczek, A. et al. 2017. Naunyn Schmiedebergs Arch. Pharmacol.

PMID: # 28622294  Wang, X.|Wu, H.|Yu, W.|Liu, J.|Peng, J.|Liao, N.|Zhang, J.|Zhang, X.|Hai, C.| et al. 2017. Cell Death Differ. 24: 1588-1597.

PMID: # 28285191  Wu, H.|Yu, W.|Meng, F.|Mi, J.|Peng, J.|Liu, J.|Zhang, X.|Hai, C.|Wang, X.| et al. 2017. Redox Biol. 12: 300-310.

Citations 1 to 10 of 18 total

What is the expected appearance of this product?

Asked by: chemicalsmg
Thank you for your question. IBMX: sc-201188 is expected to be a white to off-white solid.
Answered by: Chemical Support 3
Date published: 2017-04-05

What is the appropriate temperature when you say it will dissolve in DMSO with gentle warming?

Asked by: SCchem16
Thank you for your question. IBMX, sc-201188, can be dissolved in DMSO warmed to ~37ºC.
Answered by: TechService7
Date published: 2017-02-14
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Rated 5 out of 5 by from Freitag et al Freitag et al. (PubMed ID 9726632) used IBMX to regulate cyclic nucleotide mediated inhibition of 5-HT release from neuroendocrine cells by inhibiting phosphodiesterase. -SCBT Publication Review
Date published: 2015-05-31
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