I-OMe-Tyrphostin AG 538 MF: C17H12INO5
MW: 437.19

I-OMe-Tyrphostin AG 538

I-OMe-Tyrphostin AG 538 is rated 5.0 out of 5 by 1.
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Alternate Names: α-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3′,4′-dihydroxyphenyl)ketone; I-OMe-AG 538
Molecular Weight: 437.19
Molecular Formula: C17H12INO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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I-OMe-Tyrphostin AG 538 is an inhibitor of IGF-1 (insulin growth factor 1 receptor) protein tyrosine kinase.


References

1. Blum, G., et al. 2000. Biochemistry. 39: 15705-15712. PMID: 11123895

Physical State :
Solid
Solubility :
Soluble in methanol, and DMSO (50 mg/ml).
Storage :
Store at -20° C
IC50 :
Intestinal alkaline phosphatase: IC50 = <195 nM (mouse); Intestinal alkaline phosphatase: IC50 = 4560 nM (human); Alkaline phosphatase, tissue-nonspecific isozyme: IC50 = 5880 nM (human); Large T antigen: IC50 = 7170 nM (Simian virus 40); IGF1R autophosphorylation: IC50 = ~3.4 µM; phosphorylation of poly: IC50 = ~2 µM
pK Values :
pKa: 7.46 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD03453582
SMILES :
COC1=C(C(=CC(=C1)/C=C(\\C#N)/C(=O)C2=CC(=C(C=C2)O)O)I)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Maturana Maturana-Teixeira S; et al. (PubMed ID: 25274047) utilized I-OMe-Tyrphostin AG 538 as an inhibitor of the IGF-I receptor to determine (Na(+)/K(+))-ATPase activity in rat retinas. -SCBT Publication Review
Date published: 2015-02-03
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