I-BET 151 HydrochlorideA BET bromodomain (BRD) inhibitor

I-BET 151 Hydrochloride (CAS 1300031-49-5 (non HCl Salt))

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 65ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: GSK1210151A; 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one hydrochloride
Application: A BET bromodomain (BRD) inhibitor
CAS Number: 1300031-49-5 (non HCl Salt)
Purity: ≥98%
Molecular Weight: 451.91
Molecular Formula: C23H21N5O3•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

I-BET 151 Hydrochloride is a BET bromodomain (BRD) inhibitor and blocks recruitment of BET to chromatin. I-BET 151 play key roles in many cellular processes, including antiinflammatory gene expression, apoptosis induction, mitosis, and viral/host interaction by controlling the conformation of histone acetylation-dependent chromatin complexes. Studies have shown that I-BET 151 increased ApoA1 expression within the nanomolar range in human hepatic cell line HepG2. The upregulation by I-BET 151 suggested potential antiinflammatory activities upon administration.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (100 mM).
Storage :
Store at -20° C
IC50 :
NOMO1 cell line: IC50 = 15 nM; MV4;11 cell line: IC50 = 26 nM; MOLM13 cell line: IC50 = 120 nM; RS4;11 cell line: IC50 = 192 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
C1=C(C(=CC2=C1C3=C(C=N2)NC(N3[C@@H](C4=NC=CC=C4)C)=O)C5=C(C)ON=C5C)OC.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

I-BET 151 Hydrochloride  Product Citations

See how others have used I-BET 151 Hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27276402  Suzuki, K. et al. 2016. Anticancer Drugs. 27: 756-65.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 93ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 36ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.