I-BET 151 Hydrochloride is a BET bromodomain (BRD) inhibitor and blocks recruitment of BET to chromatin. I-BET 151 play key roles in many cellular processes, including antiinflammatory gene expression, apoptosis induction, mitosis, and viral/host interaction by controlling the conformation of histone acetylation-dependent chromatin complexes. Studies have shown that I-BET 151 increased ApoA1 expression within the nanomolar range in human hepatic cell line HepG2. The upregulation by I-BET 151 suggested potential antiinflammatory activities upon administration.
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