Hypoestoxide, Hypoestes roseaA naturally occurring, cell-permeable diterpene

Hypoestoxide, Hypoestes rosea (CAS 88498-46-8)

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Application: A naturally occurring, cell-permeable diterpene
CAS Number: 88498-46-8
Molecular Weight: 376.49
Molecular Formula: C22H32O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Hypoestoxide, Hypoestes rosea is a naturally occurring, cell-permeable diterpene with anti-inflammatory properties. Hypoestoxide, Hypoestes rosea is a selective and direct IKK (IκB kinase) inhibitor in TNF-α stimulated HeLa cells, which prevents NF-κB activation. Hypoestoxide, Hypoestes rosea also inhibits the nitric oxide production by IL-1β or IL-17 stimulated chondrocytes.


1. Ojo-Amaize, E A., et al., 2001. Hypoestoxide, a novel anti-inflammatory natural diterpene, inhibits the activity of IkappaB kinase. Cellular immunology. 209(2): 149-57. PMID: 11446747
2. Ojo-Amaize, Emmanuel A., et al., 2002. Hypoestoxide, a natural nonmutagenic diterpenoid with antiangiogenic and antitumor activity: possible mechanisms of action. Cancer research. 62(14): 4007-14. PMID: 12124334
3. Pulai, Judit I., et al., 2005. NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments. Journal of immunology (Baltimore, Md. : 1950). 174(9): 5781-8. PMID: 15843581

Physical State :
Solubility :
Soluble in DMSO (3 mg/ml)(slight warming may be required), and ethanol (5 mg/ml).
Storage :
Store at -20° C
Density :
~1.15 g/cm3 (Predicted)
Refractive Index :
n20D ~1.53 (Predicted)
IC50 :
bFGF-induced angiogenesis: IC50 = 10 nM; IκB kinase: IC50 = 24 µM (TNF-α stimulated HeLa cells); VEGF-induced cell proliferation: IC50 = 28.6 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :

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Certificate of Analysis

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