Hypericin was originally isolated from Hypericum perforatum L. (St. John's Wort). Can be additionally isolated via irradiation of oxypenicilliopsin produced by Penicilliopsis clavariaeformis. A potent and selective inhibitor of PKC (protein kinase C) and additionally reported to inhibit Casein Kinase II (CKII), MAP Kinase, Insulin R, EGFR, PI-3 Kinase. Hypericin is also noted to possess antiviral activity and is of interest in HIV studies. Hypericin is of interest in studies investigating photodynamic treatment of tumors and has been reported to be cytotoxic to some tumor cell lines when Hypericin is photoactivated. Hypericin is an inhibitor of EGFR.
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See how others have used Hypericin. Click on the entry to view the PubMed entry .
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