Hyodeoxycholic acid methyl ester (CAS 2868-48-6)

Hyodeoxycholic acid methyl ester is a methylated derivative of hyodeoxycholic acid, a bile acid involved in the emulsification and absorption of dietary fats. In research, this compound is primarily used to study bile acid metabolism, lipid digestion, and the regulatory mechanisms of cholesterol homeostasis. By incorporating hyodeoxycholic acid methyl ester into experimental setups, researchers can investigate the enzymatic activities responsible for bile acid synthesis and conjugation, particularly the roles of bile acid methyltransferases and hydroxylases. One of the key areas of study involving this compound is its impact on the solubilization and transport of lipids within the digestive system. Hyodeoxycholic acid methyl ester serves as a model compound to examine the interactions between bile acids and dietary fats, providing insights into the mechanisms of fat absorption and the formation of micelles. These studies help explain how modifications in bile acid structure influence their physicochemical properties and biological functions. Additionally, hyodeoxycholic acid methyl ester is used in research to explore its effects on the modulation of gene expression related to lipid metabolism. Researchers utilize this compound to study its interactions with nuclear receptors such as FXR (farnesoid X receptor), which play crucial roles in regulating bile acid synthesis and maintaining lipid and cholesterol homeostasis. These investigations contribute to a deeper understanding of bile acid biochemistry and its broader implications in metabolic regulation and lipid transport.