Hymenialdisine Analogue 1 CAS: 693222-51-4
MF: C15H13N5O2
MW: 295.30
A potent inhibitor of a variety of kinases.

Hymenialdisine Analogue 1 (CAS 693222-51-4)

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Alternate Names: 5-(2-Amino-5-oxo-1,5-dihydroimidazol-4-ylidene)-3,4,5,10-tetrahydro-2H-azepino[3,4-b]indol-1-one
Application: Hymenialdisine Analogue 1 is a potent inhibitor of a variety of kinases
CAS Number: 693222-51-4
Molecular Weight: 295.30
Molecular Formula: C15H13N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Hymenialdisine Analogue 1 is an indole derivative of Hymenialdisine, a potent inhibitor of a variety of kinases including MEK-1, GSK-3B, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar concentrations. This compound exhibits very potent inhibition of Chk2 activity in the low nanomolar range (IC50=8nM). Exhibits an increased selectivity for the checkpoint kinases over natural Hymenialdisine.


References

Sharma, V., and Tepe, J.J.: Bioorg. & Medicinal Chem. Letters, 14, 4319 (2004), Sharma, V., et al.: J. Med. Chem., 47, 3700 (2004)

Physical State :
Solid
Solubility :
Soluble in Butanol and DMSO
Storage :
Store at -20° C
Melting Point :
>241° C (dec.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C\1CNC(=O)C2=C(/C1=C\3/C(=O)N=C(N3)N)C4=CC=CC=C4N2

Download SDS (MSDS)

Certificate of Analysis

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