Hydroxyurea CAS: 127-07-1
MF: CH4N2O2
MW: 76.05
An inducer of apoptosis by inhibiting DNA synthesis via ribonucleotide reductase inhibition.

Hydroxyurea (CAS 127-07-1)

Hydroxyurea | CAS 127-07-1 is rated 5.0 out of 5 by 1.
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Alternate Names: Hydroxycarbamide
Application: Hydroxyurea is an inducer of apoptosis by inhibiting DNA synthesis via ribonucleotide reductase inhibition
CAS Number: 127-07-1
Purity: ≥99%
Molecular Weight: 76.05
Molecular Formula: CH4N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Hydroxyurea is a demonstrated antineoplastic agent, which is believed to block DNA replication by inhibiting R1 and R2 (ribonucleotide reductase) via destruction of the free radical at the enzymes active site. Induces apoptosis of in vitro myelogenous leukemia lymphocytes, and the phosphorylation of FADD and p53.


References

1. Anand, S., et al. 1995. Cancer Lett. 88: 101-105. PMID: 7850765
2. Davies, B.W., et al. 2009. Mol. Cell. 36: 845-860. PMID: 20005847
3. Lu, X., et al. 2010. Cancer Sci. 101: 609-615. PMID: 20028385
4. Gui, C.Y., et al. 1997. Cell Res. 7: 91-97. PMID: 9261566
5. Hendricks, S.P. and Mathews, C.K. 1998. J. Biol. Chem. 273: 29519-29523. PMID: 9792659

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), hot alcohol (freely), and DMSO.
Storage :
Store at 4° C
Melting Point :
135° C
Boiling Point :
244.72° C (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.50 (Predicted)
IC50 :
L1210: IC50 = 21.38 µM (mouse); P388: IC50 = 32 µM (mouse)
Ki Data :
Carbonic anhydrase IV: Ki= 113 µM (human); Carbonic anhydrase IX: Ki= 23 µM (human); Carbonic anhydrase II: Ki= 28 µM (human); Carbonic anhydrase VA: Ki= 31 µM (human)
pK Values :
pKa: 10.56 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
YT4900000
PubChem CID :
3657
Merck Index :
14: 4848
MDL Number :
MFCD00007943
EC Number :
204-821-7
Beilstein Registry :
1741548
SMILES :
C(=O)(N)NO

Download SDS (MSDS)

Certificate of Analysis

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Hydroxyurea (CAS 127-07-1)  Product Citations

See how others have used Hydroxyurea (CAS 127-07-1). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 14 total

PMID: # 30297532  Barnes, RP. et al. 2018. Cancer Res.

PMID: # 29103612  Reitsma, JM. et al. 2017. Cell. 171: 1326-1339.e14.

PMID: # 22851130  Gillies, AT. et al. 2012. Molecular bioSystems. 8: 2901-8.

PMID: # 16159883  Niida, H. et al. 2005. J. Biol. Chem. 280(47): 39246-39252.

PMID: # 12670898  Wu, H. et al. 2003. Cancer Res. 63: 1515-1519.

PMID: # 12615712  Xue, L. et al. 2003. Cancer Res. 63: 980-986.

PMID: # 12930944  Schultz, N. et al. 2003. Nucleic Acids Res. 31(17): 4959-4964.

PMID: # 12163450  Jin, K. et al. 2002. J. Clin. Invest. 110: 311-319.

PMID: # 11571274  Burma, S. et al. 2001. J. Biol. Chem. 276: 42462-42467.

PMID: # 11103783  Zhao, H. et al. 2000. Cancer Res. 60: 6276-6280.

Citations 1 to 10 of 14 total
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Rated 5 out of 5 by from An increase in phosphorylated Cdc2 p34 protein An increase in phosphorylated Cdc2 p34 protein observed by WB in HeLa cells after treatment with Hydroxyurea. -SCBT QC
Date published: 2015-02-08
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