HU-331A hydroxylquinone cannabidiol analog

HU-331 (CAS 137252-25-6)

HU-331 | CAS 137252-25-6 is rated 5.0 out of 5 by 1.
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Synonym: Cannabidiol hydroxyquinone; 3-hydroxy-2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-pentylcyclohexa-2,5-diene-1,4-dione
Application: A hydroxylquinone cannabidiol analog
CAS Number: 137252-25-6
Purity: ≥95%
Molecular Weight: 328.44
Molecular Formula: C21H28O3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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HU-331 is a hydroxylquinone cannabidiol analog that exhibits potent antineoplastic activity on a variety of human cancer cell lines. HU-331 is an inhibitor of Topo II.


References

1 Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Current Medicinal Chemistry 6 635-664 (1999). 2 Martin, B.R., Mechoulam, R., Razdan, R.K. Discovery and characterization of endogenous cannabinoids. Life Sci 65 573-595 (1999). 3 Kogan, N.M., Rabinowitz, R., Levi, P., et al. Synthesis and antitumor activity of quinonoid derivatives of cannabinoids. J Med Chem 47 3800-3806 (2004).

Formulation :
Solution in methyl acetate
Physical State :
Liquid
Solubility :
Soluble in ethanol (~20 mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml), 1 solution of ethanol:PBS (pH 7.2) (~0.5 mg/ml), and water (0.5 mg/ml).
Storage :
Desiccate at -20° C
Boiling Point :
57° C
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
Raji and Jurkat lymphoma cells : EC5050 = 0.2 µg/ml (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11393311
MDL Number :
MFCD08062159
SMILES :
CCCCCC1=CC(=O)C(=C(C1=O)O)[C@@H]2C=C(CC[C@H]2C(=C)C)C

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Certificate of Analysis

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HU-331  Product Citations

See how others have used HU-331. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26887982  Del Río, C. et al. 2016. Sci Rep. 6: 21703.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Regal Regal, KM. et al. (PubMed 25409338) reported that HU-331 is a catalytic inhibitor of topoisomerase II . -SCBT Publication Review
Date published: 2015-03-26
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