Anti-Hox11 Antibody (1D7) is a mouse monoclonal IgG1Hox11 antibody, cited in 4 publications, provided at 200 µg/ml
epitope mapping within amino acids 261-330 of Hox11 of human origin
Anti-Hox11 Antibody (1D7) is recommended for detection of Hox11 of mouse, rat and human origin by WB and IP
Anti-Hox11 Antibody (1D7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
TransCruz reagent for Gel Supershift and ChIP applications (sc-12760 X, 200 µg/0.1 ml)
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Hox11 (1D7): sc-12760.
At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Hox11 Antibody (1D7). This work is in progress.
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Labware ships FedEx Ground free of charge to the contiguous US
Hox11 Antibody (1D7) is a high quality monoclonal Hox11 antibody (also designated TLX1 antibody) suitable for the detection of the Hox11 protein of mouse, rat and human origin. Hox11 Antibody (1D7) is available as both the non-conjugated anti-Hox11 antibody form, as well as multiple conjugated forms of anti-Hox11 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. The Hox11 gene, termed an orphan homeobox gene, as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. The human Hox11 gene maps to chromosome 10q24 and has been implicated in the chromosomal translocation t(7;10)(q24;q11) that occurs in T-cell acute lymphoblastic leukemia (T-ALL). The t(7:10) translocation occurs between the Hox11 gene and the T-cell receptor (TCR) delta-chain gene and is a result of aberrant physiological recombinational events at the early stages of T-cell development. The Hox11 gene is normally expressed in the splanchnic anlage arising from the splanchnic mesoderm. Homozygous Hox11-deficient mice have no spleen, while all other splanchnic derivatives develop normally. Spleen development starts and proceeds normally in Hox11-deficient mice to a specific stage of embryogenesis, when the spleen anlage becomes fully absorbed.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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