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Homo Sildenafil (CAS 642928-07-2)

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Application: A new analog of sildenafil

CAS Number: 642928-07-2

Molecular Weight: 488.60

Molecular Formula: C₂₃H₃₂N₆O₄S

* Refer to Certificate of Analysis for lot specific data (including water content).

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SDS & Certificate of Analysis

Homo Sildenafil is a new analog of Sildenafil (sc-338584). Sildenafil is a selective inhibitor of the type 5 cGMP phosphodiesterase (PDE5 inhibitor) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin-induced small intestinal ulceration formation through an NO/cGMP- dependent mechanism.

References

1. Koh, H.L. and Woo, S.O. 2000. Drug Saf. 23: 351-362. PMID: 11085343
2. Seftel, A.D. 2004. Clin Cardiol. 27: I14-I19. PMID: 15115191
3. Bednar, M.M. 2008. Curr Opin Investig Drugs. 9: 754-759. PMID: 18600581
4. Kato, N., et al. 2009. Dig. Dis. Sci. 54: 2346-2356. PMID: 19101800

Physical State :

Solid

Solubility :

Soluble in Chloroform, Dichloromethane and Methanol

Storage :

Store at -20° C

Melting Point :

192-194° C

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

24756844

SMILES :

CCCC1=NN(C)C2=C1N=C(NC2=O)C1=CC(=CC=C1OCC)S(=O)(=O)N1CCN(CC)CC1

Download SDS (MSDS)

Certificate of Analysis

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