Homo SildenafilA new analog of sildenafil

Homo Sildenafil (CAS 642928-07-2)

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Application: A new analog of sildenafil
CAS Number: 642928-07-2
Molecular Weight: 488.60
Molecular Formula: C23H32N6O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Homo Sildenafil is a new analog of Sildenafil (sc-338584). Sildenafil is a selective inhibitor of the type 5 cGMP phosphodiesterase (PDE5 inhibitor) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin-induced small intestinal ulceration formation through an NO/cGMP- dependent mechanism.


References

1. Koh, H.L. and Woo, S.O. 2000. Drug Saf. 23: 351-362. PMID: 11085343
2. Seftel, A.D. 2004. Clin Cardiol. 27: I14-I19. PMID: 15115191
3. Bednar, M.M. 2008. Curr Opin Investig Drugs. 9: 754-759. PMID: 18600581
4. Kato, N., et al. 2009. Dig. Dis. Sci. 54: 2346-2356. PMID: 19101800

Physical State :
Solid
Solubility :
Soluble in Chloroform, Dichloromethane and Methanol
Storage :
Store at -20° C
Melting Point :
192-194° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
24756844
SMILES :
CCCC1=NN(C)C2=C1N=C(NC2=O)C1=CC(=CC=C1OCC)S(=O)(=O)N1CCN(CC)CC1

Download SDS (MSDS)

Certificate of Analysis

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