HNMPA-(AM)3Insulin receptor tyrosine kinase inhibitor

HNMPA-(AM)3 (CAS 120944-03-8)

HNMPA-(AM)3 | CAS 120944-03-8 is rated 5.0 out of 5 by 1.
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Synonym: Hydroxy-2-naphthalenylmethylphosphonic Acid Trisacetoxymethyl Ester
Application: Insulin receptor tyrosine kinase inhibitor
CAS Number: 120944-03-8
Purity: ≥98%
Molecular Weight: 454.36
Molecular Formula: C20H23O10P
* Refer to Certificate of Analysis for lot specific data (including water content).
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HNMPA-(AM)3 is a cell-permeable analog of HNMPA (sc-205714) that yields the parent compound via cleavage by cytosolic esterases. HNMPA-(AM)3 acts as an insulin R (Insulin receptor tyrosine kinase) inhibitor. It has also been shown to inhibit tyrosine autophosphorylation of the human insulin receptor.


References

1. Saperstein, R., et al. 1989. Biochemistry. 28: 5694-5701. PMID: 2550060
2. Baltensperger, K., et al. 1992. Proc. Natl. Acad. Sci. U.S.A. 89: 7885-7889. PMID: 1381504

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in DMSO (20 mg/ml), and ethanol (20 mg/ml).
Storage :
Store at -20° C
Melting Point :
90.27° C (Predicted)
Boiling Point :
573.06° C at 760 mmHg (Predicted)
Density :
1.33 g/mL (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
IC50 :
insulin receptor tyrosine kinase: IC50 = 100 µM; insulin-stimulated glucose oxidation: IC50 = 10 µM (isolated rat adipocytes); tyrosine autophosphorylation: IC50 = 200 µM (human insulin receptor)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3619
MDL Number :
MFCD00236443
SMILES :
CC(=O)OCOC(C1=CC2=CC=CC=C2C=C1)P(=O)(OCOC(=O)C)OCOC(=O)C

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Certificate of Analysis

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HNMPA-(AM)3  Product Citations

See how others have used HNMPA-(AM)3. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 29236310  Rodriguez-Monterrosas, C. et al. 2018. J. Cell. Biochem. 119: 4061-4071.

PMID: # 27065867  Fan, BS. et al. 2016. Frontiers in pharmacology. 7: 79.

PMID: # 25761600  Choi, KH. et al. 2015. Molecular brain. 8: 9.

PMID: # 23696913  Vanderstraete, M. et al. 2013. PLoS Negl Trop Dis. 7: e2226.

Citations 1 to 4 of 4 total

Dear Sir/Madam, I have received the product sc-221730 but there was no datasheet included, only material safety datasheet. Could you provide me the datasheet in order for me to dissolve the lyophilized product. Thanks in advance

Asked by: Yeliz Yilmaz
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis. You may request a lot-specific Certificate Of Analysis on our website. This chemical, HNMPA-(AM)3 (CAS 120944-03-8), is soluble in DMSO (> 20 mg/ml) or 100% ethanol (> 20 mg/ml).
Answered by: Technical Support
Date published: 2017-01-31
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Rated 5 out of 5 by from Choi KH;et al Choi KH;et al. (PubMed ID: 25761600) demonstrated that the neuroproliferation effects of alpha-lipoic acid was inhibited by HNMPA (AM)3 (insulin receptor inhibitor) in rats. -SCBT Publication Review
Date published: 2015-05-13
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