HMN-214 (CAS 173529-46-9)
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HMN-214 shows potent and broad-spectrum anti-tumor activity against various cancer cells, including HeLa, PC-3, DU-145, MIAPaCa-2, U937, MCF-7, A549, and WiDr, with a mean IC50 value of 118 nM. HMN-176 is also cytotoxic to drug-resistant human and murine cell lines, including P388/CDDP, P388/VCR, K2/CDDP, and K2/VP-16, with IC50 values ranging from 143 nM–265 nM. In HeLa cells, HMN-176 (3 μM) blocks cell cycle at G2/M phase.. HMN-176 (3 μM) down-regulates the expression of the multi-drug resistance gene (MDR1), due to the disturbance of NF-Y transcription factor binding to the MDR1 promoter. HMN-176 (250 nM–2.5 μM) inhibits meiotic spindle assembly and aster formation of Spisula oocytes. HMN-176 (2.5 μM) also inhibits aster microtubule formation from human centrosomes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HMN-214, 5 mg | sc-364507 | 5 mg | $260.00 | |||
HMN-214, 50 mg | sc-364507A | 50 mg | $1484.00 |