Anti-HMG-1/HMGB1 Antibody (HAP46.5) is a mouse monoclonal IgG1 κ HMG-1/HMGB1 antibody, cited in 44 publications, provided at 100 µg/ml
raised against full length recombinant HMG-1 of human origin
recommended for detection of HMG-1 of mouse, rat, human and Arabadopsis origin by WB, IP and ELISA; also reactive with additional species, including canine
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of HMG-1/HMGB1 (HAP46.5): sc-56698.
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for HMG-1/HMGB1 Antibody (HAP46.5) for WB applications. These reagents are now offered in bundles with HMG-1/HMGB1 Antibody (HAP46.5) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
HMG-1 Antibody (HAP46.5) is a high quality monoclonal HMG-1 antibody(also designated HMGB1 antibody, or HMG1 antibody) suitable for the detection of the HMG-1 protein of mouse, rat, human and a origin. HMG-1 Antibody (HAP46.5) is available as the non-conjugated anti-HMG-1 antibody. High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFκB family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.